Evolutionary Rescue Through Partly Heritable Phenotypic Variability

Genetics
Oana Carja, Joshua B Plotkin

Abstract

Environmental variation is commonplace, but unpredictable. Populations that encounter a deleterious environment can sometimes avoid extinction by rapid evolutionary adaptation. Phenotypic variability, whereby a single genotype can express multiple different phenotypes, might play an important role in rescuing such populations from extinction. This type of evolutionary bet-hedging need not confer a direct benefit to a single individual, but it may increase the chance of long-term survival of a lineage. Here, we develop a population genetic model to explore how partly heritable phenotypic variability influences the probability of evolutionary rescue and the mean duration of population persistence in changing environments. We find that the probability of population persistence depends nonmonotonically on the degree of phenotypic heritability between generations: some heritability can help avert extinction, but too much heritability removes any benefit of phenotypic variability. Partly heritable phenotypic variation is particularly advantageous when it extends the persistence time of a declining population and thereby increases the chance of rescue via beneficial mutations at linked loci. We discuss the implications of these result...Continue Reading

References

Jun 20, 2020·FEMS Microbiology Reviews·Valentine Lagage, Stephan Uphoff
Aug 6, 2020·Proceedings. Biological Sciences·James H PenistonRobert D Holt
Jun 17, 2020·Evolution; International Journal of Organic Evolution·Matteo Tomasini, Stephan Peischl

Citations

Nov 6, 1989·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M Smith
Sep 8, 2001·Science·S R Palumbi
Aug 17, 2004·Science·Nathalie Q BalabanStanislas Leibler
Feb 3, 2005·Genetics·Edo KussellStanislas Leibler
Jun 17, 2006·Nature Reviews. Microbiology·Bruce R Levin, Daniel E Rozen
Aug 2, 2006·Molecular Microbiology·David Dubnau, Richard Losick
Dec 5, 2006·Nature Reviews. Microbiology·Kim Lewis
Mar 14, 2007·Theoretical Population Biology·Maria Conceição Serra, Patsy Haccou
Oct 25, 2007·Nature Reviews. Cancer·Julio A Aguirre-Ghiso
Mar 26, 2008·Nature Genetics·Murat AcarAlexander van Oudenaarden
Jun 10, 2008·Annual Review of Microbiology·Jan-Willem VeeningOscar P Kuipers
Jul 30, 2008·The American Naturalist·H Allen Orr, Robert L Unckless
May 29, 2009·Genetics·Marcel SalathéMarcus W Feldman
Jun 27, 2009·PLoS Genetics·Frank JohannesVincent Colot
Aug 8, 2009·Ecology Letters·Graham Bell, Andrew Gonzalez
Jun 10, 2010·Annual Review of Microbiology·Kim Lewis
Jun 10, 2011·Genetics·Hildegard Uecker, Joachim Hermisson
Dec 5, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Guillaume MartinOphélie Ronce
Dec 5, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Luis-Miguel ChevinSimon Fellous
Dec 5, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andrew GonzalezMichael E Hochberg
Jun 19, 2013·Cell Host & Microbe·Nadia R CohenJames J Collins
Dec 18, 2013·The American Naturalist·Hildegard UeckerJoachim Hermisson
Jul 20, 2014·Trends in Ecology & Evolution·Stephanie M CarlsonPeter A H Westley
Aug 15, 2014·PLoS Genetics·H Allen Orr, Robert L Unckless
Sep 19, 2014·Proceedings. Biological Sciences·Oana CarjaMarcus W Feldman
Nov 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Carlos A BoteroDustin R Rubenstein
Nov 28, 2014·Proceedings of the National Academy of Sciences of the United States of America·Oana CarjaMarcus W Feldman
Jan 6, 2015·Evolutionary Applications·Helen K AlexanderSebastian Bonhoeffer
May 28, 2015·Antimicrobial Agents and Chemotherapy·Bijaya SharmaKim Lewis
Dec 3, 2015·Genetics·Hildegard Uecker, Joachim Hermisson
Sep 23, 2016·Proceedings. Biological Sciences·Jaime AshanderMarissa L Baskett
Nov 22, 2016·Evolution; International Journal of Organic Evolution·J BertramJ Masel
Feb 19, 2017·Genetics·Benjamin A WilsonDmitri A Petrov
Jul 13, 2017·Scientific Reports·Oana Carja, Joshua B Plotkin

Related Concepts

Extinction, Species
Environment
Inter-Individual Biological Variation
Adaptation
Gambling, Pathological
Genetic Models for Cancer
Genetic Loci
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Evolution, Molecular
Adaptation, Physiological

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