PMID: 8986796Dec 24, 1996Paper

Evolutionary theory predicts late-life mortality plateaus

Proceedings of the National Academy of Sciences of the United States of America
L D Mueller, M R Rose

Abstract

Most demographic data indicate a roughly exponential increase in adult mortality with age, a phenomenon that has been explained in terms of a decline in the force of natural selection acting on age-specific mortality. Scattered demographic findings suggest the existence of a late-life mortality plateau in both humans and dipteran insects, seemingly at odds with both prior data and evolutionary theory. Extensions to the evolutionary theory of aging are developed which indicate that such late-life mortality plateaus are to be expected when enough late-life data are collected. This expanded theory predicts late-life mortality plateaus, with both antagonistic pleiotropy and mutation accumulation as driving population genetic mechanisms.

References

Oct 16, 1992·Science·M Barinaga
Oct 19, 1968·Nature·E B Edney, R W Gill
Sep 1, 1966·Journal of Theoretical Biology·W D Hamilton
Nov 4, 1994·Science·J W VaupelG J Lithgow
Jan 6, 1994·Nature·K A Hughes, B Charlesworth
Mar 25, 1993·Nature·L Partridge, N H Barton
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·B Charlesworth, K A Hughes

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Citations

May 12, 2005·Journal of Biosciences·Debashish Chowdhury, Dietrich Stauffer
Apr 14, 2006·Biogerontology·Michael R RoseGregory Benford
Oct 10, 2006·Biogerontology·Laurence D MuellerMichael R Rose
Apr 23, 2011·Biogerontology·Bruce A Carnes
Apr 9, 2013·Bio Systems·Andres Kriete
Nov 24, 2001·Mechanisms of Ageing and Development·George M Martin
Jun 5, 2002·Mechanisms of Ageing and Development·Daniel E L Promislow, Scott D Pletcher
Jan 28, 2003·Trends in Genetics : TIG·Alan WrightHarry Campbell
Oct 8, 1999·Trends in Ecology & Evolution·L Partridge, M Mangel
Oct 24, 2002·Neurobiology of Aging·George M Martin
Mar 16, 2001·Experimental Gerontology·B A Carnes, S J Olshansky
Apr 3, 2003·Experimental Gerontology·Laurence D MuellerMichael R Rose
Aug 14, 2003·Experimental Gerontology·Aubrey D N J de Grey
Jun 26, 1999·Heredity·B J Zwaan
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·K W Wachter
Jan 12, 2012·Rejuvenation Research·Parvin ShahrestaniMichael R Rose
Sep 26, 2001·Proceedings. Biological Sciences·L Demetrius
Dec 3, 2010·Proceedings. Biological Sciences·Daniel A Levitis
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M R Rose, L D Mueller
Mar 24, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael B Bonsall
Nov 27, 2002·Evolution; International Journal of Organic Evolution·Michael R RoseLaurence D Mueller
Nov 27, 2007·Biology Direct·Michael R Rose, Todd H Oakley
Jul 1, 2010·Patient Related Outcome Measures·Paul A Bourne, Neva South-Bourne
Nov 22, 2013·Genome Biology and Evolution·Molly K BurkeAnthony D Long
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·J S Weitz, H B Fraser
Oct 31, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Felix ZajitschekAlexei A Maklakov
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Y Azbel'
May 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristen Hawkes
Feb 29, 2008·Journal of Genetics·Predrag ErcegMladen Davidovic
Jan 17, 2009·Journal of Genetics·Michael R RoseLaurence D Mueller
Feb 7, 2012·Theoretical Population Biology·Maxim Finkelstein
Oct 6, 2009·Experimental Gerontology·Laurence D MuellerCasandra L Rauser
Jun 9, 2009·Theoretical Population Biology·Ting Li, James J Anderson
Oct 28, 2008·Journal of Theoretical Biology·Frédéric Gosselin, Jean-Dominique Lebreton
Dec 26, 2006·Journal of Theoretical Biology·Mark BebbingtonRicardas Zitikis
May 1, 2009·Journal of Evolutionary Biology·R A Laird, T N Sherratt
Jun 5, 2007·Evolution; International Journal of Organic Evolution·Michael R RoseLaurence D Mueller
Jan 13, 2006·Journal of Evolutionary Biology·C L RauserM R Rose
Apr 11, 2012·Journal of Evolutionary Biology·P ShahrestaniL D Mueller

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