PMID: 16532225Mar 15, 2006Paper

Evolutive standard base excess and serum lactate level in severe sepsis and septic shock patients resuscitated with early goal-directed therapy: still outcome markers?

Clinics
Marcelo ParkLuiz Monteiro da Cruz Neto

Abstract

To compare the evolution of standard base excess and serum lactate level between surviving and non surviving patients with severe sepsis and septic shock resuscitated with early goal-directed therapy. This is a retrospective study in an intensive care unit of a university tertiary hospital where 65 consecutive severe sepsis and septic shock patients were observed without any intervention in the treatment by the authors of this report. In our study, the mortality of severe sepsis and septic shock patients was 38%. The central venous oxygen saturation of both groups was above 70% after the resuscitative period, excluding the second day of the non survivors group (69.8%). After the second day, the central venous oxygen saturation was significantly higher in the survivors group (P < .001). Standard base excess was initially low in both groups, but from the second day on, the correction of standard base excess was significantly more successful and linear in the survivor group (P < .001). Lactate levels were similar during the evolution of both groups. Although evolutive standard base excess and serum lactate level are still outcome markers in severe sepsis and septic shock patients resuscitated with early goal-directed therapy, othe...Continue Reading

Citations

Jul 14, 2010·Journal of Intensive Care Medicine·Colleen B Kjelland, Dennis Djogovic
Aug 28, 2010·Shock·Fernando José da Silva Ramos, Luciano César Pontes Azevedo
Jun 18, 2015·Therapeutic Hypothermia and Temperature Management·Karelle LéonErwan L'Her
Sep 19, 2012·ANZ Journal of Surgery·Chi-Min ParkSung Kim
Jun 21, 2012·Annals of Clinical Biochemistry·Hazel-Ann BorthwickChristopher Chaloner

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