Evolving biopsy techniques for the diagnosis of neuroblastoma in children

Journal of Pediatric Surgery
Giovanni CampagnaBindi J Naik-Mathuria

Abstract

To compare the adequacy and safety of percutaneous core needle biopsy and surgical wedge biopsy of neuroblastoma in children. A retrospective review of patients who underwent biopsy for intermediate- or high-risk neuroblastoma at our institution between 2011 and 2015 was performed (recent cohort). Procedure details and outcomes were collected and analyzed using descriptive statistics and Wilcoxon rank tests; P < 0.05 was considered significant. Published data from 2002 to 2010 were compared (historic cohort). Since 2011, percutaneous, ultrasound-guided, core needle biopsy has been more commonly utilized (47% (16/34) recent vs. 25% (7/28) historic; P = 0.07), and the number of core needle samples increased from median 7 (historic) to 25 (recent). Complications decreased (21% (7/34) recent vs. 64% (18/28) historic; P < 0.01). Biopsy adequacy in the recent cohort was similar (94% percutaneous vs. 89% surgical; P = 1.00), which is improved from the historic cohort (71% percutaneous vs. 100% surgical; P = 0.06). Larger tumors were more likely to have a percutaneous biopsy (82 ± 37 cm percutaneous vs. 47 ± 29 cm surgical; P = 0.04). When multiple cores are obtained, percutaneous core needle biopsy is adequate for complete tissue diag...Continue Reading

Citations

Feb 20, 2020·Pediatric Blood & Cancer·Richard E OvermanErika A Newman
Jul 16, 2019·Pediatric Radiology·Kishore MinhasPremal A Patel
Jan 20, 2019·Children·Kyle J Van Arendonk, Dai H Chung
Jun 26, 2020·Pediatric Surgery International·Manna ZhengTianyou Yang
Feb 11, 2021·AJR. American Journal of Roentgenology·Anat IlivitzkiMyriam Ben-Arush
Jul 18, 2020·Journal of Pediatric Surgery·Daniel S RheeUNKNOWN American Pediatric Surgical Association Cancer Committee
Apr 10, 2021·Journal of Cellular Physiology·Praveen BhoopathiPaul B Fisher
Jun 21, 2021·Pediatric Surgery International·Courtney L DevinLoren Berman

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