Evolving Boolean regulatory networks with epigenetic control

Bio Systems
Larry Bull

Abstract

The significant role of epigenetic mechanisms within natural systems has become increasingly clear. This paper uses a recently presented abstract, tunable Boolean genetic regulatory network model to explore aspects of epigenetics. It is shown how dynamically controlling transcription via a DNA methylation-inspired mechanism can be selected for by simulated evolution under various single and multicellular scenarios. Further, it is shown that the effects of such control can be inherited without detriment to fitness.

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Citations

Feb 24, 2018·Journal of Evolutionary Biology·Andreas OdoricoArnaud Le Rouzic

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