Evolving challenges to model human diseases for translational research.

Cell and Tissue Research
Amanda P Beck, David K Meyerholz

Abstract

Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant changes in the landscape of animal modeling. For example, newer techniques have greatly expanded the use and successful application of large animal models such as pigs for translational studies. The evolving types and species of animal models can influence the research landscape in terms of facilities, expertise, reproducibility and funding streams, which creates new challenges for research studies. It is also important that investigators are prepared to address the necessity of their animal model research and capable to educate the public regarding its value.

References

Feb 28, 2004·BMJ : British Medical Journal·Pandora PoundUNKNOWN Reviewing Animal Trials Systematically (RATS) Group
Oct 13, 2006·JAMA : the Journal of the American Medical Association·Daniel G Hackam, Donald A Redelmeier
Dec 19, 2006·BMJ : British Medical Journal·Pablo PerelKhalid S Khan
Jan 27, 2007·BMJ : British Medical Journal·Daniel G Hackam
Sep 1, 2007·Nature Cell Biology·Nadia Rosenthal, Steve Brown
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christopher S RogersMichael J Welsh
Sep 27, 2008·Science·Christopher S RogersMichael J Welsh
Mar 20, 2009·Journal of the Royal Society of Medicine·Michael B Bracken
Mar 27, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Bernhard AignerEckhard Wolf
Sep 14, 2012·Science Translational Medicine·John P A Ioannidis
Apr 12, 2014·American Journal of Primatology·Kimberley A PhillipsMary Lou Voytko
Aug 12, 2014·The Journal of Clinical Investigation·Jessica C SierenChristopher S Rogers
Dec 3, 2014·Drug Discovery Today·Caroline J Zeiss
Oct 30, 2015·Toxicologic Pathology·David K MeyerholzDavid A Stoltz
Nov 5, 2015·ALTEX·Mardas DaneshianMarcel Leist
Nov 28, 2015·Science·Jocelyn Kaiser
Sep 23, 2016·JCI Insight·Ashley L CooneyPaul B McCray
Dec 30, 2016·Future Science OA·Françoise Barré-Sinoussi, Xavier Montagutelli
Jan 17, 2017·Temperature : Multidisciplinary Biomedical Journal·Rachele McAndrew, Stephen I Helms Tillery
Jun 18, 2017·Science·David Grimm
Aug 16, 2017·Veterinary Pathology·David K MeyerholzHeather A Flaherty
Aug 29, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·David K MeyerholzJill M Weimer
Feb 14, 2018·Science Translational Medicine·Mitchell C ColemanJames A Martin
Feb 23, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·David K MeyerholzPaul B McCray
Jun 1, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·David K Meyerholz, Amanda P Beck
Aug 23, 2018·Veterinary Pathology·David K MeyerholzAmanda P Beck
Sep 27, 2018·Nature Neuroscience·Ted M DawsonClotilde Lagier-Tourenne
Dec 7, 2018·Nature·Matthias LänginJan-Michael Abicht

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Citations

Apr 21, 2020·Cell and Tissue Research·D K MeyerholzB Singh
Dec 18, 2020·Veterinary Pathology·Mark James HoenerhoffAmanda P Beck
Apr 29, 2021·Veterinary Pathology·David K MeyerholzAlessandra Piersigilli
Jul 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Hao WangJens Nielsen

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Methods Mentioned

BETA
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Software Mentioned

ARRIVE

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