Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease

JAMA Ophthalmology
Paul J SteptoeMalcolm G Semple

Abstract

The 2-year ophthalmic sequelae of Ebola virus disease (EVD) in survivors of the 2013 to 2016 epidemic is unknown and may have public health implications for future outbreaks. To assess the potential for uveitis recurrence, the behavior of dark without pressure, and visual outcomes in a cohort of Sierra Leonean survivors of EVD 2 years following the 2013 to 2016 Ebola epidemic. Prospective, 1-year observational cohort study performed between 2016 and 2017 at 34 Military Hospital, Freetown, Sierra Leone. Participants included survivors of EVD who reported ocular symptoms since Ebola treatment unit discharge and were participants of a previous case-control study. Participants were invited for ophthalmic reexamination and finger-prick blood sampling for immunoglobulin G (IgG) to Toxoplasma gondii and HIV. Ebola virus disease. Primary outcome measure: comparative ultra-widefield retinal imaging. Secondary outcome measures: visual acuity and detection of IgG to T gondii and HIV. Of 57 survivors of EVD who underwent repeated ophthalmic evaluation, 37 were women (64.9%). Mean (SD) age was 31.9 (11.1) years. Median interval between first and last examination was 370 days (interquartile range [IQR], 365-397.5 days), and median time from ...Continue Reading

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Citations

Feb 24, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mamadou Saliou Kalifa DialloEric Delaporte

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Krio
SPSS

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