Evolving M-protein pattern in patients with smoldering multiple myeloma: impact on early progression

Leukemia
Carlos Fernández de LarreaLaura Rosiñol

Abstract

Smoldering multiple myeloma (SMM) is a biologically heterogeneous, clinically defined entity with a variable rate of progression to symptomatic multiple myeloma (MM). Reliable markers for progression are critical for the development of potential therapeutic interventions. We retrospectively evaluated the predictive value of the evolving pattern of serum M-protein among other progression risk factors in 206 patients with SMM diagnosed between 1973 and 2012. Median time from recognition of evolving type to progression into symptomatic MM was 1.1 years (95% CI 0.5-2.0) and progression rate at 3 years was 71%. Development of the evolving type drastically worsened the prognostic estimation made at diagnosis for every covariate predictive of progression (serum M-protein size, bone marrow plasma cell infiltration, immunoparesis and Mayo Clinic risk). On average, the hazard ratio for progression to symptomatic MM increased to 5.1 (95% CI 3.4-7.6) after recognition of the evolving type. In conclusion, in patients with SMM the evolving pattern accurately predicts the risk of early progression to symptomatic disease, thereby allowing the identification of ultra-high risk patients who would be candidates for immediate therapy.

References

Jun 12, 1980·The New England Journal of Medicine·R A Kyle, P R Greipp
Feb 22, 2002·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Dec 3, 2002·International Journal of Methods in Psychiatric Research·Lonni R SchultzNaomi Breslau
Nov 18, 2003·British Journal of Haematology·L RosiñolE Montserrat
Aug 24, 2005·British Journal of Haematology·Laura RosiñolEmili Montserrat
Jun 22, 2007·The New England Journal of Medicine·Robert A KyleS Vincent Rajkumar
Dec 23, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joan BladéRobert A Kyle
Feb 24, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jens HillengassHartmut Goldschmidt
Aug 5, 2011·The New England Journal of Medicine·S Vincent RajkumarRobert A Kyle
Aug 2, 2013·The New England Journal of Medicine·María-Victoria MateosJesús-F San Miguel
Dec 3, 2014·The Lancet Oncology·S Vincent RajkumarJesus F San Miguel
Apr 4, 2015·Blood·S Vincent RajkumarMaría-Victoria Mateos
Feb 28, 2016·The Oncologist·Jo CaersMonika Engelhardt

❮ Previous
Next ❯

Citations

Mar 26, 2019·Expert Review of Hematology·José-Ángel HernándezJuan-José Lahuerta
Feb 1, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Noopur Raje, Andrew J Yee
Nov 15, 2018·Blood Advances·María-Victoria Mateos, Verónica González-Calle
Nov 15, 2019·HemaSphere·María-Victoria MateosPieter Sonneveld
Oct 13, 2020·Hematology Reports·Alessandra RomanoFrancesco Di Raimondo
Oct 18, 2020·Blood Cancer Journal·María-Victoria MateosJesús San-Miguel
Sep 11, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Su-Hsin ChangKenneth R Carson
Jan 28, 2021·Journal of Clinical Medicine·Niccolo' BolliPellegrino Musto
Dec 22, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Timothy Schmidt, Natalie Callander
Mar 7, 2020·Best Practice & Research. Clinical Haematology·Chutima Kunacheewa, Elisabet E Manasanch
May 1, 2021·Cancers·David F MorenoCarlos Fernández de Larrea
May 14, 2021·Current Hematologic Malignancy Reports·Timothy M Schmidt, Natalie S Callander

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis

Software Mentioned

SPSS Statistics
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Hematologic Malignancy Reports
María-Victoria Mateos, Jesús F San Miguel
American Society of Clinical Oncology Educational Book
María-Victoria Mateos, Jesús-F San Miguel
© 2022 Meta ULC. All rights reserved