Evolving Relevance of Neuroproteomics in Alzheimer's Disease

Methods in Molecular Biology
S ListaH Hampel

Abstract

Substantial progress in the understanding of the biology of Alzheimer's disease (AD) has been achieved over the past decades. The early detection and diagnosis of AD and other age-related neurodegenerative diseases, however, remain a challenging scientific frontier. Therefore, the comprehensive discovery (relating to all individual, converging or diverging biochemical disease mechanisms), development, validation, and qualification of standardized biological markers with diagnostic and prognostic functions with a precise performance profile regarding specificity, sensitivity, and positive and negative predictive value are warranted.Methodological innovations in the area of exploratory high-throughput technologies, such as sequencing, microarrays, and mass spectrometry-based analyses of proteins/peptides, have led to the generation of large global molecular datasets from a multiplicity of biological systems, such as biological fluids, cells, tissues, and organs. Such methodological progress has shifted the attention to the execution of hypothesis-independent comprehensive exploratory analyses (opposed to the classical hypothesis-driven candidate approach), with the aim of fully understanding the biological systems in physiology a...Continue Reading

Citations

Oct 10, 2018·Nature Reviews. Neurology·Harald HampelKaj Blennow
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Eleanor DrummondThomas Wisniewski
Nov 30, 2018·Acta Neuropathologica·José Luis MolinuevoKaj Blennow
Nov 28, 2020·Neuroscience·Jesús Avila, George Perry
Apr 2, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Liu ShiAlejo J Nevado-Holgado

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