Evolving research trends in bioinformatics

Briefings in Bioinformatics
Carolina Perez-IratxetaJonathan D Wren


The cross-disciplinary nature of bioinformatics entails co-evolution with other biomedical disciplines, whereby some bioinformatics applications become popular in certain disciplines and, in turn, these disciplines influence the focus of future bioinformatics development efforts. We observe here that the growth of computational approaches within various biomedical disciplines is not merely a reflection of a general extended usage of computers and the Internet, but due to the production of useful bioinformatics databases and methods for the rest of the biomedical scientific community. We have used the abstracts stored both in the MEDLINE database of biomedical literature and in NIH-funded project grants, to quantify two effects. First, we examine the biomedical literature as a whole and find that the use of computational methods has become increasingly prevalent across biomedical disciplines over the past three decades, while use of databases and the Internet have been rapidly increasing over the past decade. Second, we study the recent trends in the use of bioinformatics topics. We observe that molecular sequence databases are a widely adopted contribution in biomedicine from the field of bioinformatics, and that microarray ana...Continue Reading


Oct 17, 2009·BMC Bioinformatics·Javier RíosOswaldo Trelles
Jan 15, 2013·Journal of Biomedical Semantics·Johan Karlsson, Oswaldo Trelles
May 10, 2012·PLoS Computational Biology·Christos A Ouzounis
May 23, 2015·Methods of Information in Medicine·E S Chen, I N Sarkar
Dec 7, 2007·EMBO Reports·Carolina Perez-IratxetaMiguel A Andrade-Navarro
Mar 25, 2009·FEBS Letters·Chanchal Kumar, Matthias Mann
Apr 18, 2017·Journal of Biomedical Semantics·Yuqing Mao, Zhiyong Lu

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