Evolving resistance among Gram-positive pathogens

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jose M MunitaCesar A Arias

Abstract

Antimicrobial therapy is a key component of modern medical practice and a cornerstone for the development of complex clinical interventions in critically ill patients. Unfortunately, the increasing problem of antimicrobial resistance is now recognized as a major public health threat jeopardizing the care of thousands of patients worldwide. Gram-positive pathogens exhibit an immense genetic repertoire to adapt and develop resistance to virtually all antimicrobials clinically available. As more molecules become available to treat resistant gram-positive infections, resistance emerges as an evolutionary response. Thus, antimicrobial resistance has to be envisaged as an evolving phenomenon that demands constant surveillance and continuous efforts to identify emerging mechanisms of resistance to optimize the use of antibiotics and create strategies to circumvent this problem. Here, we will provide a broad perspective on the clinical aspects of antibiotic resistance in relevant gram-positive pathogens with emphasis on the mechanistic strategies used by these organisms to avoid being killed by commonly used antimicrobial agents.

References

Oct 5, 1978·The New England Journal of Medicine·M R JacobsR Austrian
Sep 1, 1983·The Journal of Clinical Investigation·B E Murray, B Mederski-Samaroj
Sep 18, 2002·Antimicrobial Agents and Chemotherapy·S H MarshallL B Rice
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Louis B RiceLaurent Gutmann
Dec 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrice Courvalin
May 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean B PatelFred C Tenover
Aug 18, 2006·The New England Journal of Medicine·Vance G FowlerUNKNOWN S. aureus Endocarditis and Bacteremia Study Group
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fred C Tenover, Robert C Moellering
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael M MwangiAlexander Tomasz
Feb 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dawn M SievertJeffrey C Hageman
Apr 2, 2008·Antimicrobial Agents and Chemotherapy·Ritu BanerjeeHenry F Chambers
Aug 15, 2009·Nature Reviews. Microbiology·Henry F Chambers, Frank R Deleo
Sep 5, 2009·The Journal of Clinical Investigation·Frank R DeLeo, Henry F Chambers
Feb 11, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gracia MoralesMiguel Sánchez-García
Aug 24, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hector BonillaJohn P Quinn
Jan 13, 2011·Biochimica Et Biophysica Acta·Jawad K MuraihMichael Palmer
Jun 8, 2011·Antimicrobial Agents and Chemotherapy·Jacqueline M LaMarreAlexander S Mankin
Jun 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abhay DhandGeorge Sakoulas
Sep 9, 2011·The New England Journal of Medicine·Cesar A AriasGeorge M Weinstock
Jan 10, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sylvie ParerEstelle Jumas-Bilak
Mar 8, 2012·Future Microbiology·Regine HakenbeckPatrick Maurer
Mar 9, 2012·The Journal of Antimicrobial Chemotherapy·Rodrigo E MendesKlaudia Kosowska-Shick
Mar 17, 2012·Nature Reviews. Microbiology·Cesar A Arias, Barbara E Murray
Mar 28, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cesar A AriasBarbara E Murray
Oct 19, 2012·Virulence·Brian L Hollenbeck, Louis B Rice
Dec 5, 2012·The Journal of Antimicrobial Chemotherapy·Vincent Cattoir, Roland Leclercq
Dec 12, 2012·Annals of the New York Academy of Sciences·Arnold S BayerHans-Georg Sahl
Mar 13, 2013·Antimicrobial Agents and Chemotherapy·Cristina García-de-la-MàriaUNKNOWN Hospital Clinic Experimental Endocarditis Study Group
Jun 5, 2013·Antimicrobial Agents and Chemotherapy·Yang WangJianzhong Shen

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Citations

Feb 27, 2016·Annals of Emergency Medicine·Mustapha Saheed, Richard Rothman
Sep 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Keith A Rodvold
Dec 19, 2017·Journal of Clinical Pharmacology·Randall K HooverSue K Cammarata
Jun 8, 2018·Expert Opinion on Pharmacotherapy·Nicholas J MercuroErica S Herc
Jul 13, 2016·Antimicrobial Agents and Chemotherapy·Jeshina JanardhananMayland Chang
Oct 17, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mohammad Abdallah, Mohammad Al-Saafin
Jan 1, 2019·Expert Review of Respiratory Medicine·Paula PeyraniGlenn S Tillotson
Sep 19, 2019·Antimicrobial Agents and Chemotherapy·Richard R WatkinsMichael Z David
Aug 14, 2019·Journal of Bacteriology·Lauren R HammondPrahathees J Eswara
Sep 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christian E Sandrock, Andrew F Shorr
Nov 3, 2016·Cold Spring Harbor Perspectives in Medicine·William R MillerCesar A Arias
Oct 24, 2017·The Journal of Antimicrobial Chemotherapy·Mohsen HeidaryMehdi Goudarzi
Jun 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rafik KaramanZeinab Breijyeh
Aug 8, 2021·International Journal of Molecular Sciences·Isabella Hernández-Aristizábal, Iván Darío Ocampo-Ibáñez

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