Evolving role of FDG-PET/CT in prognostic evaluation of resectable gastric cancer

World Journal of Gastroenterology : WJG
Emilio De RaffeleBruno Cola

Abstract

Gastric cancer (GC) remains a leading cause of cancer death worldwide. Radical gastrectomy is the only potentially curative treatment, and perioperative adjuvant therapies may improve the prognosis after curative resection. Prognosis largely depends on the tumour stage and histology, but the host systemic inflammatory response (SIR) to GC may contribute as well, as has been determined for other malignancies. In GC patients, the potential utility of positron emission tomography/computed tomography (PET/CT) with the imaging radiopharmaceutical 18F-fluorodeoxyglucose (FDG) is still debated, due to its lower sensitivity in diagnosing and staging GC compared to other imaging modalities. There is, however, growing evidence that FDG uptake in the primary tumour and regional lymph nodes may be efficient for predicting prognosis of resected patients and for monitoring tumour response to perioperative treatments, having prognostic value in that it can change therapeutic strategies. Moreover, FDG uptake in bone marrow seems to be significantly associated with SIR to GC and to represent an efficient prognostic factor after curative surgery. In conclusion, PET/CT technology is efficient in GC patients, since it is useful to integrate other ...Continue Reading

References

Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T WaddellUNKNOWN European Society of Radiotherapy and Oncology (ESTRO)
Oct 25, 2013·Nature Reviews. Cancer·Eran ElinavRichard A Flavell
Apr 26, 2014·Journal of Gastric Cancer·Mijin Yun
May 2, 2014·World Journal of Gastroenterology : WJG·Chen-Xi Wu, Zhao-Hui Zhu
May 9, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Louis de MestierOlivier Bouché
May 10, 2016·Lancet·Eric Van CutsemHans Prenen
Sep 28, 2016·Current Problems in Surgery·Syed A AhmadAlexander A Parikh
Apr 22, 2017·World Journal of Gastroenterology : WJG·Jeong Won LeeSang Mi Lee

❮ Previous
Next ❯

Citations

Mar 11, 2020·Abdominal Radiology·Esma A AkinRobert K Zeman
Aug 9, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Dengsai PengYue Chen
Aug 17, 2021·Radiologic Clinics of North America·Brandon A Howard, Terence Z Wong

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
imaging techniques

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.