PMID: 18407109Sep 1, 1992Paper

Evolving role of Gonadotropin-Releasing Hormone antagonists

Trends in Endocrinology and Metabolism : TEM
K Gordon, G D Hodgen

Abstract

GnRH antagonists, unlike GnRH agonists, do not act via "downregulation." Instead, GnRH antagonists monopolize the GnRH receptors to such an extent that endogenous GnRH is unable to bind to sufficient numbers of GnRH receptors to provoke release of LH/FSH. This fundamental difference in the mechanism of action of GnRH antagonists versus GnRH agonists is anticipated to result in clinical benefits for certain applications.

References

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Citations

Feb 1, 1995·Cellular and Molecular Neurobiology·S C Sealfon, R P Millar
Aug 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R E FelberbaumK Diedrich
Jun 16, 2005·Animal Reproduction Science·A M Padula
Jun 17, 2003·Clinical Obstetrics and Gynecology·Nathalie Chabbert-BuffetPhilippe Bouchard

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