Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy.

Pharmacology & Therapeutics
Miaomiao YeXueqiong Zhu

Abstract

The lysyl oxidase (LOX) family is comprised of LOX and four LOX-like proteins (LOXL1, LOXL2, LOXL3, and LOXL4), and mainly functions in the remodeling of extracellular matrix (ECM) and the cross-linking of collagen and elastic fibers. Recently, a growing body of research has demonstrated that LOX family is critically involved in the regulation of cancer cell proliferation, migration, invasion and metastasis. In this review, we discuss the roles of LOX family members in the development and progression of different types of human cancers. Furthermore, we also describe the potential inhibitors of LOX family proteins and highlight that LOX family might be an important therapeutic target for cancer therapy.

Citations

Jan 2, 2021·Cancers·Sylvain D ValletSylvie Ricard-Blum
Dec 30, 2020·International Journal of Molecular Sciences·Hung-Yu LinPei-Yi Chu
May 16, 2021·Nature Reviews. Molecular Cell Biology·Shuvasree SenGuptaJames E Bear
Jul 3, 2021·International Journal of Molecular Sciences·Ya-Ling YangYing-Hsien Huang
Aug 8, 2021·International Journal of Molecular Sciences·Talita de S LaurentinoSueli M Oba-Shinjo
Aug 28, 2021·Communications Biology·Laura Martinez-VidalMassimo Alfano
Aug 28, 2021·Virchows Archiv : an International Journal of Pathology·Ning WangXiaowei Zhu
Sep 19, 2021·The FEBS Journal·Gemma Serra-Bardenys, Sandra Peiró

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Related Papers

OncoTargets and Therapy
Alejandro Mayorca-Guiliani, Janine T Erler
International Journal of Molecular Sciences
Tong-Hong WangTzong-Ming Shieh
Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society
Qian Xiao, Gaoxiang Ge
© 2021 Meta ULC. All rights reserved