Evolving Therapeutic Strategies in the Inflammatory Bowel Disease

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Soo Young Na, Won Moon

Abstract

It is important to have effective therapeutic strategies and goals in clinical practice and research of inflammatory bowel disease. Conventional end points for clinical trials in Crohn's disease and ulcerative colitis have been based on composite indices, such as the Crohn's Disease Activity Index and the Mayo Clinic Score. Although these indices have been shown to reduce the intestinal injury to some extent, satisfactory results have not been obtained in improving the quality of life of patients. Recently, alternative measures of outcome and definitions of response are being developed beyond symptoms. Mucosal healing as a clinical response and treatment goal has showed better long-term outcomes. Patient-reported outcomes (PROs) are emerging instrument directly created by patient to quantify symptoms. Coprimary realistic treatment 'target', comprising mucosal healing and PROs, can offer a clinically valid endpoint and can be readily applied in practice compare to existing composite indices. 'Treat-to-target' algorithm based on mucosal healing and PROs, in which therapy is progressively intensified until a specific personal treatment goal is reached, could improve quality of life of patient by reducing disease-related disability...Continue Reading

References

Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
Jan 1, 1988·Journal of Clinical Epidemiology·R S SandlerL L Kupper
Feb 17, 2006·Gut·E F StangeUNKNOWN European Crohn's and Colitis Organisation
Oct 13, 2006·Health and Quality of Life Outcomes·UNKNOWN U.S. Department of Health and Human Services FDA Center for Drug Evaluation and ResearchUNKNOWN U.S. Department of Health and Human Services FDA Center for Devices and Radiological Health
Aug 8, 2007·Gastroenterology·Kathrine Frey FrøslieUNKNOWN IBSEN Group
Jul 16, 2008·Inflammatory Bowel Diseases·James D LewisJonas H Ellenberg
Jan 29, 2009·The American Journal of Gastroenterology·Gary R LichtensteinUNKNOWN Practice Parameters Committee of American College of Gastroenterology
Mar 18, 2009·Inflammatory Bowel Diseases·Javier P GisbertJosé Maté
Jan 14, 2010·The American Journal of Gastroenterology·Asher KornbluthUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Apr 16, 2010·The New England Journal of Medicine·Jean Frédéric ColombelUNKNOWN SONIC Study Group
Dec 3, 2010·Journal of Crohn's & Colitis·A DignassUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Mar 1, 2008·Journal of Crohn's & Colitis·S P L TravisUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jul 28, 2011·Inflammatory Bowel Diseases·Fernando MagroElizabeth Benito Garcia
Jan 24, 2012·Gut·Charles N BernsteinUNKNOWN Epidemiology and Natural History Task Force of the International Organization for the Study of Inflammatory Bowel Disease (I
May 23, 2012·The American Journal of Gastroenterology·Laura E TargownikCharles N Bernstein
Sep 5, 2012·The American Journal of Gastroenterology·Laurent Peyrin-BirouletEdward V Loftus
Aug 6, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurent Peyrin-BirouletWendy Kampman
Sep 17, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Guillaume BouguenWilliam J Sandborn
Feb 19, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nicolas WillietLaurent Peyrin-Biroulet
Apr 10, 2014·Journal of Crohn's & Colitis·William J SandbornRemo Panaccione
Jul 2, 2014·Inflammatory Bowel Diseases·Jin-Feng LinBo Jiang
Aug 17, 2014·Gastroenterology·Barrett G LevesqueJean-Frederic Colombel
Aug 26, 2015·The American Journal of Gastroenterology·L Peyrin-BirouletJ-F Colombel
Oct 18, 2015·Gut·Mahmoud H MosliBarrett G Levesque

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Citations

Jun 14, 2019·Gut and Liver·Soo-Young Na, Won Moon

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