Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer

Cancers
Laura L ThompsonKirk J McManus

Abstract

Cancer is a devastating disease that claims over 8 million lives each year. Understanding the molecular etiology of the disease is critical to identify and develop new therapeutic strategies and targets. Chromosome instability (CIN) is an abnormal phenotype, characterized by progressive numerical and/or structural chromosomal changes, which is observed in virtually all cancer types. CIN generates intratumoral heterogeneity, drives cancer development, and promotes metastatic progression, and thus, it is associated with highly aggressive, drug-resistant tumors and poor patient prognosis. As CIN is observed in both primary and metastatic lesions, innovative strategies that exploit CIN may offer therapeutic benefits and better outcomes for cancer patients. Unfortunately, exploiting CIN remains a significant challenge, as the aberrant mechanisms driving CIN and their causative roles in cancer have yet to be fully elucidated. The development and utilization of CIN-exploiting therapies is further complicated by the associated risks for off-target effects and secondary cancers. Accordingly, this review will assess the strengths and limitations of current CIN-exploiting therapies, and discuss emerging strategies designed to overcome the...Continue Reading

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Citations

Dec 29, 2017·Cancers·Natalia Vargas-RondónMilena Rondón-Lagos
Jun 4, 2019·International Journal of Molecular Sciences·Dian WangWeiwei Zhang
Apr 26, 2019·Journal of Cellular Physiology·Saleheh RezapourAli Hassanzadeh
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Aug 5, 2021·Investigative Ophthalmology & Visual Science·Xi ChenJing Zhuang
Aug 28, 2021·International Journal of Molecular Sciences·Laura L ThompsonKirk J McManus
Oct 5, 2021·Endocrinology·Katrina M PiemonteRuth A Keri
Nov 19, 2021·Human Molecular Genetics·Michaela C L PalmerKirk J McManus
Jan 14, 2022·Molecular Biology Reports·Shujaat HussainHongmin Liu

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Methods Mentioned

BETA
single-cell sequencing
xenografts

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