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Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance

Current Opinion in Structural Biology

Jan 15, 2020

Francesc Xavier Ruiz, Eddy Arnold

Abstract

The essential role of reverse transcription in the HIV life cycle is illustrated by the fact that half of the ∼30 FDA-approved drugs for HIV treatment target HIV-1 reverse transcriptase (RT). Even though more than 160 structures of RT deposited in the Protein Data Bank (PDB) have reveal...read more

Mentioned in this Paper

HIV Infections
HIV-1
Complex (molecular entity)
Compound (Substance)
Finding
Reverse Transcription
RNA
Reverse Transcriptase Polymerase Chain Reaction
Structure
Reverse transcriptase, Human immunodeficiency virus 1
1
Paper Details
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Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance

Current Opinion in Structural Biology

Jan 15, 2020

Francesc Xavier Ruiz, Eddy Arnold

PMID: 31935541

DOI: 10.1016/j.sbi.2019.11.011

Abstract

The essential role of reverse transcription in the HIV life cycle is illustrated by the fact that half of the ∼30 FDA-approved drugs for HIV treatment target HIV-1 reverse transcriptase (RT). Even though more than 160 structures of RT deposited in the Protein Data Bank (PDB) have reveal...read more

Mentioned in this Paper

HIV Infections
HIV-1
Complex (molecular entity)
Compound (Substance)
Finding
Reverse Transcription
RNA
Reverse Transcriptase Polymerase Chain Reaction
Structure
Reverse transcriptase, Human immunodeficiency virus 1
1
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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