Evolving White Matter Injury following Pediatric Traumatic Brain Injury.

Journal of Neurotrauma
Brenda Bartnik-OlsonStephen Ashwal

Abstract

This study is unique in that it examines the evolution of white matter injury very early and at 12 months post-injury in pediatric patients following traumatic brain injury (TBI). Diffusion tensor imaging (DTI) was acquired at two time-points: acutely at 6-17 days and 12 months following a complicated mild (cMild)/moderate (mod) or severe TBI. Regional measures of anisotropy and diffusivity were compared between TBI groups and against a group of age-matched healthy controls and used to predict performance on measures of attention, memory, and intellectual functioning at 12-months post-injury. Analysis of the acute DTI data using tract based spatial statistics revealed a small number of regional decreases in fractional anisotropy (FA) in both the cMild/mod and severe TBI groups compared with controls. These changes were observed in the occipital white matter, anterior limb of the internal capsule (ALIC)/basal ganglia, and corpus callosum. The severe TBI group showed regional differences in axial diffusivity (AD) in the brainstem and corpus callosum that were not seen in the cMild/mod TBI group. By 12-months, widespread decreases in FA and increases in apparent diffusion coefficient (ADC) and radial diffusivity (RD) were observed...Continue Reading

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Citations

Jun 16, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Banesh JainDevendra Kumar Purohit

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Software Mentioned

MATLAB
bwmorph
SPM5
LONI Brain Parser
FSL
TBSS
SPSS

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