PMID: 8443760Mar 15, 1993Paper

Ewing sarcoma of bone in infants and toddlers. A clinicopathologic report from the Intergroup Ewing's Study

Cancer
S J MaygardenM Nesbit

Abstract

Nineteen patients with Ewing sarcoma of bone, each younger than 3 years of age at the time of initial presentation, are reported. These children represent an unusually young age group for documented Ewing sarcoma and represent 2.6% of all patients registered in the Intergroup Ewing's Sarcoma Study (IESS). The diagnosis was made on combined histologic, clinical, and radiographic grounds and was supported by immunohistochemistry in nine patients and electron microscopic study in eight patients. Immunohistochemical studies showed no staining against neuro-specific enolase, chromogranin, or S-100 in any patients, and in only one in nine patients were results of such studies focally positive against Leu-7. The most marked clinical variation between this group of infants and the general IESS patient population was a striking predominance of female patients in the younger age group (P < 0.001). There was a trend toward more rib, pelvis, and proximal long bone tumors in the infants and toddlers. The overall survival rate of the infants was 56%, almost identical to the survival rates of the older children. All of the infants who died of disease did so within 4 years. Extended follow-up as long as 9.9 years has found no late deaths attri...Continue Reading

References

Jan 1, 1992·Medical and Pediatric Oncology·H S NicholsonJ Byrne
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·S DaugaardT Schiødt
Feb 1, 1989·Pediatric Clinics of North America·L P Dehner
Dec 1, 1986·Cancer·R M WilkinsK K Unni
Oct 31, 1985·The New England Journal of Medicine·R C SeegerD Hammond
Feb 1, 1971·Cancer·M E Kadin, K G Bensch
Dec 1, 1984·The American Journal of Surgical Pathology·R JaffeM Goodman
Mar 15, 1981·Cancer·K JentzschN L Gerber

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Citations

May 13, 1999·The British Journal of Radiology·H Y HsiehS F Ko
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Maria TsokosPaul S Dickman
Jul 16, 2015·Pediatric Blood & Cancer·Thalia WongSteven G DuBois
Dec 1, 1995·Journal of Surgical Oncology·A J RenardJ R van Horn
Jul 20, 2007·Pediatric Blood & Cancer·Henk van den BergHeribert Jürgens
Jun 2, 2000·American Journal of Otolaryngology·S PostovskyM W Arush
Jun 1, 1997·Pediatric Clinics of North America·M T Myers, G H Thompson
Dec 3, 2014·Journal of the Egyptian National Cancer Institute·Shikha GoyalBidhu Kalyan Mohanti
May 15, 2016·Brazilian Journal of Otorhinolaryngology·Neslihan YaprakAlper Tunga Derin
Apr 8, 2016·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Louis P Dehner
Jun 8, 2000·Medical and Pediatric Oncology·K L WeberN Jaffe
Oct 15, 1995·Cancer·R S YangR al-Shaikh
Oct 1, 2007·The Canadian Journal of Plastic Surgery = Journal Canadien De Chirurgie Plastique·Tatiana Karine Simon CypelRonald Melvin Zuker
Sep 14, 2001·Clinical Orthopaedics and Related Research·J R CusmariuK Jaffe
Oct 9, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·David M Parham
May 19, 2001·Clinical Orthopaedics and Related Research·P S RoseF J Frassica
Jan 26, 1999·Clinical Orthopaedics and Related Research·M DurbinS Zoger
Dec 25, 2009·Advances in Anatomic Pathology·Shaoying Li, Gene P Siegal

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