Ewing sarcoma of the head and neck: The Mayo Clinic experience

Head & Neck
Michael D OlsonEric J Moore

Abstract

Treatment options of Ewing sarcoma of the head and neck include surgery, radiotherapy (RT), and chemoradiotherapy. However, local control can be challenging. We conducted a retrospective review of all patients with head and neck Ewing sarcoma treated from 1972 to 2015 at a single tertiary care hospital. Seventeen patients met criteria (median 21 years, range 5-58 years; 5 women). Mean follow-up was 10.4 years (range 2.2-39 years). Tumors occurred commonly in the cervical spine (5/17), the skull (3/17), and the paranasal sinuses (3/17). A total of 14 of 17 patients underwent surgical resection, 9 with gross total resection. After multimodality therapy, the 5-year overall survival (OS) and recurrence-free survival (RFS) was 87% and 75%, respectively. Combined multimodal treatment resulted in a 5-year OS and RFS of 87% and 75%, respectively. Aggressive surgical resection with adjuvant chemoradiotherapy should be considered. Although negative margin surgery is the goal, subtotal resection may be acceptable in the setting of adjuvant treatment.

References

Sep 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E O BurgertP Thomas
Oct 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M E NesbitJ M Kissane
Aug 1, 1997·Pediatric Clinics of North America·H E Grier
Dec 16, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K FizaziB B Nguyen
Jan 2, 2003·Head & Neck·Leonard H WexlerLanny G Close
Nov 13, 2003·Clinical Orthopaedics and Related Research·Bruno FuchsFranklin H Sim
Sep 27, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Pedro Infante-CossioFrancisco Gavilan-Carrasco
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Trang H LaSuzanne L Wolden
May 30, 2006·Pediatric Blood & Cancer·Arnold C PaulinoB-Chen Wen
Apr 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda GranowetterHolcombe E Grier
Jun 18, 2009·Current Treatment Options in Oncology·Vivek SubbiahJoseph A Ludwig
Jul 29, 2009·Pediatric Blood & Cancer·Denise A CaseyPaul A Meyers
Oct 21, 2009·American Journal of Clinical Oncology·J Taylor WhaleyRobert B Marcus
Apr 29, 2010·Current Oncology Reports·Steven J Frank, Ugur Selek
Jun 16, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruth LadensteinHeribert Jürgens
Aug 23, 2011·International Journal of Radiation Oncology, Biology, Physics·Barbara RombiTorunn I Yock
Oct 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Heribert JuergensAntonio Gualberto
Oct 11, 2012·International Journal of Pediatric Otorhinolaryngology·Giuseppe MeccarielloChristos Georgalas
Oct 24, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard B WomerAaron R Weiss
Oct 28, 2014·The Laryngoscope·Bivas BiswasSameer Bakhshi
Feb 18, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Yunseon ChoiChang-Ok Suh
Mar 25, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nabil AhmedStephen Gottschalk
May 17, 2017·Clinical Oncology : a Journal of the Royal College of Radiologists·S Frisch, B Timmermann

❮ Previous
Next ❯

Citations

Nov 28, 2019·The Laryngoscope·Sina J TorabiBenjamin L Judson
Aug 14, 2020·Journal of Neuro-oncology·J D PalmerD M Trifiletti
Nov 19, 2019·Pediatric Blood & Cancer·Shivam M KharodJulie A Bradley
Oct 27, 2018·Ophthalmic Plastic and Reconstructive Surgery·Lawrence ChanRenelle Pointdujour-Lim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Clinical Oncology
Arnold C PaulinoBin S Teh
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Michele M CorsiniLeonard L Gunderson
© 2022 Meta ULC. All rights reserved