Ewing sarcoma: The clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathway

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Annemiek M van MaldegemHans Gelderblom

Abstract

In the last three decades the outcome for patients with localised Ewing sarcoma (ES) has improved significantly since the introduction of multimodality primary treatment. However, for patients with (extra-) pulmonary metastatic and/or non-resectable relapsed disease the outcome remains poor and new treatment options are urgently needed. Currently the insulin-like growth factor 1 receptor (IGF-1R) pathway and the poly-ADP(adenosinediphosphate)-ribose-polymerase (PARP) pathway are being investigated for potential targeted therapies. IGF-1R: The IGF-1R pathway is known to be deregulated by the EWSR1-FLI1 translocation which makes it a potential target for therapy. Clinical trials have been reported in which only ES patients were treated with an IGF-1R inhibitor, either as single agent or in combination. In total 291 ES patients were included in these trials, in which two (0.7%) complete responses, 32 (11%) partial responses of which some durable, and 61 (21%) stable diseases were observed. PARP: In the presence of a PARP inhibitor DNA strand breaks cannot be efficiently repaired, leading to cell death. The first phase II trial with ES patients was recently published and showed no clinical responses, which may have been due to the ...Continue Reading

References

Jul 28, 1995·International Journal of Cancer. Journal International Du Cancer·P F BruningA A Hart
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J P PeyratA Demaille
Jan 10, 1998·The Journal of Biological Chemistry·J A ToretskyL J Helman
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·P TonioloA Zeleniuch-Jacquotte
Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·H MaackeH W Stürzbecher
Aug 16, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Ingo Burtscher, Gerhard Christofori
Jul 4, 2002·Journal of the National Cancer Institute·Manjinder S SandhuEdward L Giovannucci
May 28, 2003·Cancer Letters·Derek LeRoith, Charles T Roberts
Sep 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wen-Kai Weng, Ronald Levy
May 28, 2004·Expert Opinion on Pharmacotherapy·Carlos Rodriguez-Galindo
Jul 27, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jean-Christophe AméGilbert de Murcia
Feb 3, 2006·Cancer Research·Kathryn E O'ReillyNeal Rosen
May 26, 2006·Nature·Reuben J Shaw, Lewis C Cantley
Dec 15, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·O Shevah, Z Laron
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria C ManaraKatia Scotlandi
Apr 10, 2007·International Journal of Cancer. Journal International Du Cancer·Tomoyoshi TakenakaYoshihiko Maehara
May 15, 2007·Nature Medicine·Eva HernandoCarlos Cordon-Cardo
Mar 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonino MusolinoAndrea Ardizzoni
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meenali M ChitnisValentine M Macaulay
Nov 26, 2008·Nature Reviews. Cancer·Michael Pollak
Dec 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Christopher M HineVera Gorbunova
Jun 26, 2009·The New England Journal of Medicine·Peter C FongJohann S de Bono
Dec 17, 2009·Biochimica Et Biophysica Acta·Ryan J O DowlingNahum Sonenberg
May 18, 2010·The Lancet Oncology·UNKNOWN Endogenous Hormones and Breast Cancer Collaborative GroupAndrew W Roddam
Jul 21, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C UnderhillH Bonnefoi
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert L FerrisSoldano Ferrone
Oct 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Heribert JuergensAntonio Gualberto
Apr 3, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aung NaingRazelle Kurzrock
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William D TapAnthony Tolcher

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Citations

May 6, 2016·International Journal of Molecular Sciences·Antonina ParafioritiAnna C Berardi
Aug 24, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ian W FolkertMalay Haldar
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Patrick J GroharJoshua D Schiffman
Jan 23, 2020·Cancers·Kenji Nakano, Shunji Takahashi
Jun 3, 2017·Oncotarget·Hao-Dong FeiFeng Ji
Mar 28, 2018·La Radiologia medica·Monica MangoniLorenzo Livi
Aug 17, 2019·Cells·Eliot Osher, Valentine M Macaulay
Dec 15, 2017·Calcified Tissue International·Hannah K BrownDominique Heymann
Jun 27, 2019·Der Pathologe·H-U Schildhaus, M Evert
Nov 30, 2018·International Journal of Molecular Sciences·Kenji Nakano, Shunji Takahashi
Jul 2, 2020·OncoTargets and Therapy·Deepam PushpamBivas Biswas
Dec 3, 2020·Cancers·Stefanie de GrootJudith R Kroep
Aug 10, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Fan TangXia-Wei Wei

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