Apr 20, 2016

ExM-STORM: Expansion Single Molecule Nanoscopy

BioRxiv : the Preprint Server for Biology
Hu CangZhenmin Hong

Abstract

Recently, Chen et al. invented Expansion Microscopy, or ExM, which imprints a specimen features of interest onto a polymer hydrogel network and expands the network homogeneously to magnify sub-diffraction-limit features. However, ExM bleaches massively, 50-100% of the fluorescent molecules; thus it is not suited for single-molecule imaging. Here, we describe improved ExM that is free of bleaching, and thus can be synergically integrated with single-molecule nanoscopy, STORM.

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Mentioned in this Paper

Single Molecule Imaging
Hydrogels
X-Ray Diffraction
Microscopy
Pathologic Processes
Bleach

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