Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis.

Scientific Reports
Alastair J MossStephanie L Sellers

Abstract

Early microcalcification is a feature of coronary plaques with an increased propensity to rupture and to cause acute coronary syndromes. In this ex vivo imaging study of coronary artery specimens, the non-invasive imaging radiotracer, 18F-fluoride, was highly selective for hydroxyapatite deposition in atherosclerotic coronary plaque. Specifically, coronary 18F-fluoride uptake had a high signal to noise ratio compared with surrounding myocardium that makes it feasible to identify coronary mineralisation activity. Areas of 18F-fluoride uptake are associated with osteopontin, an inflammation-associated glycophosphoprotein that mediates tissue mineralisation, and Runt-related transcription factor 2, a nuclear protein involved in osteoblastic differentiation. These results suggest that 18F-fluoride is a non-invasive imaging biomarker of active coronary atherosclerotic mineralisation.

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Citations

Aug 7, 2021·Biomolecules·Kohsuke Shirakawa, Motoaki Sano

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Methods Mentioned

BETA
dissection

Clinical Trials Mentioned

NCT02278211

Software Mentioned

PRISM for OS X
Mediso
ImageScope
OsiriX Imaging
GraphPad
OsiriX
WiRE

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