Ex-vivo analysis of the bone microenvironment in bone metastatic breast cancer.

Journal of Mammary Gland Biology and Neoplasia
Karen M Bussard, Andrea M Mastro

Abstract

In humans, breast cancer has a predilection to metastasize to the skeleton. While the mechanism for preferential metastasis is unknown, the bone microenvironment likely provides a fertile soil for metastatic breast cancer cells. In order to examine the bone microenvironment ex-vivo following the formation of breast cancer metastases, several techniques may be employed: fluorescence stereomicroscopy, magnetic resonance imaging (MRI), microCT (microCT), immunohistochemistry, and cytokine arrays, to name a few. These methods allow for a comprehensive evaluation of the bone microenvironment during bone metastatic breast cancer. By identifying alterations in the bone niche caused by metastatic breast cancer cells, it may be possible to block or disrupt these factors through the use of targeted drugs. Appropriate therapeutic treatment would allow for an improved quality of life and longer survival time for individuals with bone metastatic breast cancer.

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Citations

Dec 3, 2014·Advanced Drug Delivery Reviews·Anna V Taubenberger
Nov 7, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Xiuli ChenTaeyong Lee
Oct 9, 2015·Yonsei Medical Journal·Yoon Sok ChungTaeyong Lee
Feb 6, 2020·International Journal of Molecular Sciences·Alexander SieberathKenny Dalgarno
Feb 17, 2017·Cancer Research·Walter JacksonAndrea M Mastro
Aug 13, 2010·Current Opinion in Supportive and Palliative Care

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