PMID: 15348751May 1, 1997Paper

Ex vivo complement protein adsorption on positively and negatively charged cellulose dialyser membranes

Journal of Materials Science. Materials in Medicine
A MahioutJ M Courtney

Abstract

An ex vivo test system was used to measure complement protein C3 and factor B adsorption onto small dialyser modules made from regenerated and modified cellulosic hollow fibre membranes in which positive diethylaminoethyl (DEAE) or negative carboxymethyl (CM) groups were introduced into the cellulose matrix. The extracorporeal system, which included test-dialysers and the dialysis environment, allowed the use of labelled proteins without contaminating the blood donors which were connected in an open-loop fashion to the extracorporeal test system. The modules were removed at selected time points from the extracorporeal system for radioactivity counting. The results were used to evaluate the mechanisms involved in complement reactions to foreign surfaces. The system therefore allowed the analysis of complement protein adsorption occurring in the dialyser modules and its relationship to the complement generation rate in the extracorporeal system to be evaluated. It was possible to demonstrate that significant complement C3 and factor B adsorption occurred in the test modules made of cellulosic membranes. Complement adsorption as a function of the pH and the release reaction of the adsorbed C3 and factor B after membrane blood perf...Continue Reading

Citations

Jul 9, 1999·Journal of Biomedical Materials Research·M KälltorpP Tengvall
Jul 9, 1999·Journal of Biomedical Materials Research·M SantinM Cannas
Feb 17, 2005·Journal of Biomedical Materials Research. Part a·L BaldwinJ A Hunt

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