Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review.

Stem Cell Research & Therapy
Joao Victor CabralKaterina Jirsova

Abstract

Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured non-limbal autologous cell type to treat bilateral LSCD. This review summarizes clinical outcomes from COMET studies published from 2004 to 2019 and reviews results with emphasis on the culture methods by which grafted cell sheets were prepared.

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Citations

Dec 17, 2020·Asia-Pacific Journal of Ophthalmology·Geetha IyerHiren Matai
Mar 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh
Apr 13, 2021·Frontiers in Bioengineering and Biotechnology·Eleonora MauriziGraziella Pellegrini

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Methods Mentioned

BETA
confocal microscopy
biopsy
FCS

Software Mentioned

IVCM
Ovid
COMET

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