Ex vivo evaluation of the NASA/DeBakey axial flow ventricular assist device. Results of a 2 week screening test

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
K KawahitoM DeBakey

Abstract

The authors investigated the antithombogenicity of the NASA/DeBakey axial flow ventricular assist device in an ex vivo calf model. The device is 3 inches in length and 1 inch in largest diameter. The pump weighs 53 g and displaces 15 ml. The unit consists of three major components: a flow straightener, a spinning inducer/impeller, and a diffuser. The impeller has rod shaped permanent magnets embedded within the six blades and is activated magnetically by a motor stator that is positioned outside the flow tube. Previous 2 day screening tests demonstrated an antithrombogenic configuration in short-term implantation. Based on the results of these 2 day screening tests, five pumps with the best configuration were implanted into a calf for 2 weeks for anti thrombogenicity confirmation. Pumps were implanted paracorporeally, and heparin was used to maintain activated clotting time to approximately 250 sec. Each pump was changed every 2 weeks as planned. During the experiment, all pumps demonstrated stable pumping. The required electric power was 7 to 8 watts and pump flow was maintained at 4 L/min. The calf was in excellent condition. Liver and renal function were maintained, plasma free hemoglobin was kept at less than 4 mg/dl (3.3 +...Continue Reading

Citations

Sep 4, 1999·The Annals of Thoracic Surgery·M E DeBakey
May 4, 2002·Seminars in Thoracic and Cardiovascular Surgery·O H Frazier
Jun 27, 2003·Current Opinion in Cardiology·Reynolds M Delgado
Jan 5, 2000·Artificial Organs·E TayamaM E Debakey
Aug 27, 1999·Artificial Organs·T W FossumM E DeBakey
Jul 3, 1998·Artificial Organs·Y Nosé
Jun 7, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kazuyoshi FukunagaYasuhiro Fukui
May 26, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·T W FossumM E DeBakey

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