Ex vivo liver resection and autotransplantation as alternative to allotransplantation for end-stage hepatic alveolar echinococcosis

Journal of Hepatology
Tuerganaili AjiHao Wen

Abstract

Radical resection is the best treatment for patients with advanced hepatic alveolar echinococcosis (AE). Liver transplantation is considered for selected advanced cases; however, a shortage of organ donors and the risk of postoperative recurrence are major challenges. The aim of this study was to assess the clinical outcomes of ex vivo liver resection and autotransplantation for end-stage AE. In this prospective study, 69 consecutive patients with end-stage hepatic AE were treated with ex vivo resection and liver autotransplantation between January 2010 and February 2017. The feasibility, safety and long-term clinical outcome of this technique were assessed. Ex vivo extended hepatectomy with autotransplantation was successful in all patients without intraoperative mortality. The median weight of the graft and AE lesion were 850 (370-1,600) g and 1,650 (375-5,000) g, respectively. The median duration of the operation and anhepatic phase were 15.9 (8-24) h and 360 (104-879) min, respectively. Six patients did not need any blood transfusion. Complications higher than IIIa according to Clavien classification were observed in 10 patients. The 30-day-mortality and overall mortality (>90 days) were 7.24% (5/69) and 11.5% (8/69), respe...Continue Reading

Citations

Jun 6, 2020·Parasite : Journal De La Société Française De Parasitologie·Dominique A VuittonUNKNOWN World Association of Echinococcosis
Aug 14, 2020·Journal of Cardiac Surgery·Alexander ChernyavskiyIvan Porshennikov
Feb 15, 2019·Clinical Microbiology Reviews·Hao WenDonald P McManus
Jan 14, 2021·Parasite : Journal De La Société Française De Parasitologie·Li WanHao Wen
Feb 26, 2020·Food and Waterborne Parasitology·L A SalmG Beldi
Dec 29, 2020·Parasite : Journal De La Société Française De Parasitologie·Zhan WangHaiNing Fan
Feb 17, 2021·Langenbeck's Archives of Surgery·Maria Baimas-GeorgeDionisios Vrochides
Mar 7, 2021·Advances in Medical Sciences·Abril Alondra Barrientos-BonillaDaniel Hernandez-Baltazar
Apr 17, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Li WanHao Wen
Jun 24, 2021·Seminars in Liver Disease·Solange Bresson-HadniFrançois Chappuis
Sep 28, 2021·Parasite : Journal De La Société Française De Parasitologie·Éléonore BrumptUNKNOWN XUUB consortium

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