Ex Vivo Metrics, a preclinical tool in new drug development.

Journal of Translational Medicine
C Gerald CurtisHugo Stephenson

Abstract

Among the challenges facing translational medicine today is the need for greater productivity and safety during the drug development process. To meet this need, practitioners of translational medicine are developing new technologies that can facilitate decision making during the early stages of drug discovery and clinical development. Ex Vivo Metrics is an emerging technology that addresses this need by using intact human organs ethically donated for research. After hypothermic storage, the organs are reanimated by blood perfusion, providing physiologically and biochemically stable preparations. In terms of emulating human exposure to drugs, Ex Vivo Metrics is the closest biological system available for clinical trials. Early application of this tool for evaluating drug targeting, efficacy, and toxicity could result in better selection among promising drug candidates, greater drug productivity, and increased safety.

References

Mar 20, 2002·Current Topics in Medicinal Chemistry·C Gerald CurtisKumar Ramu
Jul 30, 2005·Science·Jeffrey Mervis
Aug 11, 2006·The New England Journal of Medicine·Alastair J J Wood
Aug 16, 2006·The New England Journal of Medicine·Ganesh SuntharalingamNicki Panoskaltsis
Jan 17, 2007·Clinical Science·Bruce H LittmanFrancesco M Marincola

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Citations

Jan 27, 2009·Journal of Translational Medicine·Lawrence Leung
Mar 2, 2011·Disease Models & Mechanisms·Alastair G ProudfootMatthew Hind
Aug 19, 2015·Biotechnology Advances·Atanas G AtanasovHermann Stuppner
May 22, 2013·Expert Opinion on Drug Metabolism & Toxicology·Margaret Clotworthy, Kathy Archibald
Oct 7, 2010·Expert Review of Respiratory Medicine·Aaron GardnerAndrew J Fisher

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Methods Mentioned

BETA
lavage
biopsies

Software Mentioned

Vivo
Vivo Metrics
Ex

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