Ex vivo modulation of response to prednisolone in childhood acute lymphoblastic leukaemia

British Journal of Haematology
Jan Styczynski, Mariusz Wysocki

Abstract

We hypothesised that the intensity of mechanisms of glucocorticoid resistance in childhood acute lymphoblastic leukaemia might be decreased by concurrent ex vivo use of compounds with specific blocking or activating properties at different steps of the glucocorticoid intracellular pathway. The following modifiers were used: ciclosporin A, rifampicin, doxycycline, meta-iodobenzylguanidine, buthionine sulfoximine, ethacrinic acid, pentoxifylline, indomethacin, rotenone, forskolin, olomoucin, 5-aza-2'-deoxycytidine, 3-aminobenzamide, O(6)-benzylguanidine and nitroprusside sodium. All modulators sensitised lymphoblasts and potentiated prednisolone cytotoxicity in most cases indicating that various compounds, which can influence the antileukaemic effect of prednisolone during anticancer therapy, might modulate some mechanisms of glucocorticoid resistance.

References

Mar 22, 2003·British Journal of Haematology·Eric G HaarmanAnjo J P Veerman
Jul 8, 2003·The Journal of Endocrinology·R KoflerM J Ausserlechner
Aug 22, 2003·The New England Journal of Medicine·Bob LöwenbergUNKNOWN Swiss Group for Clinical Cancer Research
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jan Styczynski, Mariusz Wysocki
Jun 15, 2005·British Journal of Haematology·C D MitchellUNKNOWN Medical Research Council Childhood Leukaemia Working Party

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Citations

Apr 10, 2007·Nature Medicine·Brian L BishopSoman N Abraham
May 15, 2007·Cellular Immunology·Ana LustigDennis D Taub
Apr 9, 2008·Leukemia Research·E G HaarmanA J P Veerman
Aug 30, 2008·British Journal of Haematology·Drew ProvanRoberto Stasi

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