Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM.

Neuro-oncology
Radhika SrinivasanSarah J Nelson

Abstract

The motivation of this study was to address the urgent clinical problem related to the inability of magnetic resonance (MR) imaging measures to differentiate tumor progression from treatment effects in patients with glioblastoma multiforme (GBM). While contrast enhancement on MR imaging (MRI) is routinely used for assessment of tumor burden, therapy response, and progression-free survival in GBM, it is well known that changes in enhancement following treatment are nonspecific to tumor. To address this issue, the objective of this study was to investigate whether MR spectroscopy can provide improved biomarker surrogates for tumor following treatment. High-resolution metabolic profiles of tissue samples obtained from patients with GBM were directly correlated with their pathological assessment to determine metabolic markers that correspond to pathological indications of tumor or treatment effects. Acquisition of tissue samples with image guidance enabled the association of ex vivo biochemical and pathological properties of the tissue samples with in vivo MR anatomical and structural properties derived from presurgical MR images. Using this approach, we found that metabolic concentration levels of [Myo-inositol/total choline (MCI)...Continue Reading

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Citations

Nov 18, 2011·Nature Reviews. Cancer·Kristine GlundeSabrina M Ronen
Jan 13, 2012·Science Translational Medicine·Adam ElkhaledSarah J Nelson
Oct 22, 2013·International Journal of Computer Assisted Radiology and Surgery·Constantin RoderSotirios Bisdas
Apr 25, 2013·Der Radiologe·A Radbruch, H-P Schlemmer
Nov 4, 2015·Brain Pathology·Myriam M ChaumeilSabrina M Ronen
Mar 24, 2012·The American Journal of Surgical Pathology·Jang-Hee KimKyi Beom Lee
Oct 26, 2018·The British Journal of Radiology·Giuseppe BarisanoMeng Law
Nov 3, 2011·Current Opinion in Neurology·Janine M LupoSarah J Nelson
Mar 31, 2015·The Cancer Journal·Yan LiSarah J Nelson
Jul 19, 2017·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mojgan HojjatiLeo J Wolansky
Apr 10, 2014·Journal of Neuro-oncology·Timothy Charles RykenUNKNOWN AANS/CNS Joint Guidelines Committee
Feb 25, 2015·Journal of Neuro-oncology·David A Reardon, Hideho Okada
Jul 10, 2014·Cancer Research·Morteza EsmaeiliArend Heerschap
Dec 20, 2013·Cancer Research·Antony PrabhuPrakash Chinnaiyan
Oct 5, 2019·Radiologic Clinics of North America·Sara B StraussGloria C Chiang

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