Ex vivo optical measurements of glucose diffusion kinetics in native and diabetic mouse skin

Journal of Biophotonics
Daria K TuchinaValery V Tuchin

Abstract

The aim of this study was to estimate the glucose diffusion coefficients ex vivo in skin of mice with diabetes induced in vivo by alloxan in comparison to non-diabetic mice. The temporal dependences of collimated transmittance of tissue samples immersed in glucose solutions were measured in the VIS-NIR spectral range to quantify the glucose diffusion/permeability coefficients and optical clearing efficiency of mouse skin. The average thickness of intact healthy and diabetic skin was 0.023 ± 0.006 cm and 0.019 ± 0.005 cm, respectively. Considerable differences in optical and kinetic properties of diabetic and non-diabetic skin were found: clearing efficiency was 1.5-fold better and glucose diffusivity was 2-fold slower for diabetic skin. Experimental Setup for measuring collimated transmittance spectra of mouse skin samples.

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Citations

Dec 23, 2016·Journal of Biophotonics·Rui ShiDan Zhu
Jan 31, 2017·Journal of Biophotonics·Anton SdobnovValery Tuchin
Aug 10, 2018·Journal of Biophotonics·Fernanda R PaolilloJarbas C de Castro Neto
Dec 27, 2018·Journal of Biophotonics·Isa CarneiroValery V Tuchin
Jan 27, 2018·Journal of Molecular Modeling·Kirill V BerezinValery V Tuchin
Jul 21, 2020·Journal of Biophotonics·Daria K TuchinaValery V Tuchin
Jun 20, 2019·Biochemistry. Biokhimii︠a︡·O A SmolyanskayaV V Tuchin
Mar 16, 2018·Biomedical Optics Express·O A SmolyanskayaV V Tuchin
Jun 20, 2019·Biochemistry. Biokhimii︠a︡·A Yu SdobnovV V Tuchin

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