PMID: 6732547May 1, 1984

Ex vivo preclinical evaluation of membrane plasma separators

Artificial Organs
S MatsubaraY Nosé


Four different types of hollow-fiber membrane plasma separators, constructed of cellulose acetate, polyvinyl alcohol, polyethylene, and polymethylmethacrylate membranes, were evaluated in ex vivo dog perfusions under conditions simulating their clinical use. An arteriovenous (A-V) fistula constructed in the dogs for blood access enabled repeated access to be achieved without surgical intervention. All modules produced transient leukopenia and a reduction of platelet counts. The polymethylmethacrylate module showed minimum reductions of white blood cell counts and CH50. The early leukocyte count reduction in membrane plasmapheresis is most likely related to the magnitude of complement activation by the membrane, as is seen with hemodialysis.


Mar 25, 1968·JAMA : the Journal of the American Medical Association·L S Kaplow, J A Goffinet
Oct 1, 1980·Kidney International·A I JacobJ J Bourgoignie
Jan 1, 1980·Journal of Dialysis·J ShinM Nishioka


Oct 17, 1998·Medical Engineering & Physics·C A FernandezM Zborowski
Mar 23, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Y NoséY Abe
May 4, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Y Takenaka
May 11, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·S MurabayashiY Nosé

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