Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia

Behavioural Brain Research
Georgina S Perez-García, A Meneses

Abstract

The cyclic adenosine monophosphate (cAMP) is a second messenger and a central component of intracellular signaling pathways that regulate a wide range of biological functions, including memory. Hence, in this work, firstly the time-course of memory formation was determined in an autoshaping learning task, which had allowed the identification of testing times for increases or decreases in performance. Next, untrained, trained and overtrained groups were compared in cAMP production. Moreover, selective stimulation and antagonism of 5-HT(1A) and 5-HT(7) receptors during memory formation and cAMP production were determined. Finally, since there is scarce information about how pharmacological models of amnesia affect cAMP production, the cholinergic or glutamatergic antagonists, scopolamine and dizocilpine, were tested. The major findings of this work showed that when the time-course was determined inasmuch as training and testing sessions occurred, memory performance was graduate and progressive. Notably, for the fourth to seventh (i.e., 48-120 h following autoshaping training session) testing session performance was significantly higher from the previous ones. When animals received 5-HT(1A) and 5-HT(7) receptor agonists and antago...Continue Reading

References

Jun 5, 1999·Cellular and Molecular Life Sciences : CMLS·G Riedel
Aug 4, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·R MarksteinD Hoyer
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Meneses
Nov 10, 2001·Trends in Endocrinology and Metabolism : TEM·P R Albert, M Tiberi
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
Dec 20, 2003·Behavioural Brain Research·L Manuel-Apolinar, A Meneses
Feb 18, 2004·Current Drug Targets. CNS and Neurological Disorders·David R Thomas, Jim J Hagan
Mar 25, 2005·American Journal of Physiology. Cell Physiology·Sunita WarrierRobert D Harvey
Jun 7, 2005·Behavioural Brain Research·Georgina S Perez-García, A Meneses
Aug 16, 2005·Journal of Chemical Neuroanatomy·Ken W S Ashwell, George Paxinos
Feb 17, 2006·Behavioural Brain Research·Georgina Pérez-GarcíaAlfredo Meneses
Jul 29, 2006·Trends in Neurosciences·Iván IzquierdoMartín Cammarota
Jan 17, 2007·Neurobiology of Learning and Memory·A Meneses
Apr 10, 2007·Neuroscience and Biobehavioral Reviews·Alfredo Meneses, Georgina Perez-Garcia
Jul 14, 2007·Current Alzheimer Research·Fernanda G De FeliceSérgio T Ferreira
Jan 29, 2008·Behavioural Brain Research·G Perez-Garcia, A Meneses
Dec 17, 2008·Trends in Pharmacological Sciences·Madeleine V KingKevin C F Fone

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Citations

Jan 17, 2014·Experimental Brain Research·Mohammad SeyedabadiReza Rahimian
May 29, 2012·Neurobiology of Learning and Memory·Ruth TellezAlfredo Meneses
Sep 8, 2009·Neurobiology of Learning and Memory·A Huerta-RivasA Meneses
Apr 13, 2011·Hippocampus·Amanda J Roberts, Peter B Hedlund
Dec 21, 2011·Neurobiology of Learning and Memory·Ruth TellezAlfredo Meneses
Jun 28, 2014·Frontiers in Behavioral Neuroscience·Alfredo Meneses
May 15, 2015·PloS One·Andrew T Kempsell, Lynne A Fieber
Dec 8, 2016·Behavioural Pharmacology·Alfredo Meneses
Mar 28, 2017·Reviews in the Neurosciences·Alfredo Meneses
Feb 4, 2014·Reviews in the Neurosciences·Antonella Gasbarri, Assunta Pompili
Nov 22, 2013·Reviews in the Neurosciences·Alfredo Meneses
Feb 25, 2009·Bioorganic & Medicinal Chemistry Letters·Eduard BadarauGérald Guillaumet

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