Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice.

ASN Neuro
Derek A WainwrightKathryn J Jones

Abstract

We have previously demonstrated a neuroprotective mechanism of FMN (facial motoneuron) survival after facial nerve axotomy that is dependent on CD4(+) Th2 cell interaction with peripheral antigen-presenting cells, as well as CNS (central nervous system)-resident microglia. PACAP (pituitary adenylate cyclase-activating polypeptide) is expressed by injured FMN and increases Th2-associated chemokine expression in cultured murine microglia. Collectively, these results suggest a model involving CD4(+) Th2 cell migration to the facial motor nucleus after injury via microglial expression of Th2-associated chemokines. However, to respond to Th2-associated chemokines, Th2 cells must express the appropriate Th2-associated chemokine receptors. In the present study, we tested the hypothesis that Th2-associated chemokine receptors increase in the facial motor nucleus after facial nerve axotomy at timepoints consistent with significant T-cell infiltration. Microarray analysis of Th2-associated chemokine receptors was followed up with real-time PCR for CCR3, which indicated that facial nerve injury increases CCR3 mRNA levels in mouse facial motor nucleus. Unexpectedly, quantitative- and co-immunofluorescence revealed increased CCR3 expression...Continue Reading

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Citations

Jul 30, 2011·The Journal of Comparative Neurology·Nichole A MesnardKathryn J Jones
May 21, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chelsea R GeilKimberly Nixon
May 20, 2015·Brain, Behavior, and Immunity·Hiromi ToyodaKatsushi Tokunaga
Nov 5, 2016·Molecular and Cellular Neurosciences·Saleh A BakheetSheikh Fayaz Ahmad
Sep 3, 2011·Nature·Richard M Ransohoff
Apr 8, 2014·The Journal of Pharmacology and Experimental Therapeutics·Michelle A EricksonWilliam A Banks
Mar 2, 2011·Journal of Hypertension·Sabine S GouraudMasanobu Maeda
Apr 19, 2020·Journal of Neuroinflammation·Elizabeth M RungeKathryn J Jones
Jul 8, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kathryn J JonesVirginia M Sanders
Oct 17, 2017·Brain, Behavior, and Immunity·D O SetterK J Jones
Aug 17, 2021·Brain Communications·Anastasia LanquetinAnne-Lise Pitel

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Datasets Mentioned

BETA
PPM02946E-200

Methods Mentioned

BETA
PCRs
FCS
PCR

Software Mentioned

GEArray Expression Analysis
STAT School Pak
Image Pro Plus
GB

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