Exacerbation of liver steatosis following exposure to famine and overnutrition

Molecular Nutrition & Food Research
Zhiyuan NingYingli Lu

Abstract

People suffering from famine in early life and overnutrition in adulthood may have an increased risk for liver steatosis. We aimed to investigate the effects and mechanisms of early nutrition restriction and overnutrition on de novo lipogenesis in the liver. Three-wk-old male rats were food restricted for 4 wk and refed a high-fat or normal fat diet individually in metabolic cages for 9 wk. Weight-matched groups were also set up. Fatty acid synthetase expression was measured to estimate de novo lipogenesis in the liver. Parameters of glucose and lipid metabolism were measured with isotope assays. All four groups had comparable body weights. However, the famine high-fat diet group had the highest degree of liver steatosis, the greatest body fat ratio, and insulin resistance. Lipid accumulation, fatty acid synthetase expression, and gluconeogenesis in the liver were significantly higher in the famine and high-fat diet groups (p < 0.05). Moreover, these groups also had markedly lower muscle glucose uptake. Under famine and high-fat refeeding stress, rats were extremely susceptible to developing hepatic steatosis. This is presumably a consequence of upregulation of de novo lipogenesis and enhanced glucose flux from muscle to de nov...Continue Reading

References

Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Margreet A VeeningHenriette A Delemarre-Van De Waal
Nov 30, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A G DullooJ-P Montani
Feb 19, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Abdul G Dulloo
Dec 23, 2011·International Journal of Endocrinology·Anna AlisiValerio Nobili
Jan 10, 2012·Nutrition Reviews·Christopher Masterjohn, Richard S Bruno
Jan 27, 2012·Reproductive Biology and Endocrinology : RB&E·Hua-Ling ZhaiYing-Li Lu
Apr 23, 2013·Endocrine Journal·Katsumi Iizuka
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Laura M BreijAnita C S Hokken-Koelega
Jun 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·James FungUNKNOWN Hong Kong Liver Health Census Study Group
Jul 24, 2015·Journal of Gastroenterology and Hepatology·Jiang-Peng ChenYong-Hong Wang
Aug 19, 2015·Hormone Research in Pædiatrics·Laura M BreijAnita C S Hokken-Koelega
Mar 24, 2016·The Journal of Clinical Endocrinology and Metabolism·Ningjian WangYingli Lu
Apr 22, 2016·Nature Communications·Yuefeng TangDavid A Guertin
Sep 19, 2016·Lipids in Health and Disease·Sabina Paglialunga, Clayton A Dehn

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.