Exacerbation of pre-existing epilepsy by mild head injury: a five patient series

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
P C Tai, D W Gross

Abstract

While the risk of developing seizures following a mild head injury has been reported and is thought to be low, the effect of mild head injury on patients with a pre-existing seizure disorder has not been reported. We present a series of cases where a strong temporal relationship between mild head injury and worsening of seizure frequency was observed. Five cases were identified and reviewed in detail. Information was derived from clinic and hospital charts with attention to the degree of injury, pre- and postinjury seizure patterns and frequency. One patient has primary generalized epilepsy and four have localization related epilepsy. Prior to the head injury, three of the patients were seizure free (range: two to 24 years). The patients suffered from mild head injuries with no or transient loss of consciousness and no focal neurological deficits. In all cases, the patients experienced a worsening of seizure control within days of the injury. In one case, the patient's seizure pattern returned to baseline one year after the accident, while in the remaining four cases, the patients continue to have medically refractory seizures. A close temporal relationship between mild head injury and a worsening of seizure control was observe...Continue Reading

References

May 1, 1979·Journal of Neurosurgery·W F CavenessG H Weiss
Jul 1, 1980·Neurology·J F AnnegersL T Kurland
Jan 1, 1998·The New England Journal of Medicine·J F AnnegersW A Rocca
Sep 17, 1998·Epilepsia·L E WestbrookR Geocadin
Dec 8, 1998·Journal of Computer Assisted Tomography·C HosokawaY Morikawa
Feb 26, 2000·Epilepsia·D Clear, D W Chadwick
Jun 23, 2000·The Journal of Clinical Investigation·J F Kearney
Oct 7, 2003·Epilepsy & Behavior : E&B·Sheryl R HautShlomo Shinnar

❮ Previous
Next ❯

Citations

Jan 10, 2012·Epilepsy & Behavior : E&B·David E FriedmanRonnie S Tobias
Nov 6, 2009·Archives of Physical Medicine and Rehabilitation·Lee L SaundersJohn D Corrigan
Sep 25, 2008·Arquivos de neuro-psiquiatria·Thais Helena BuffoMaria Augusta Montenegro
Mar 1, 2006·Journal of Neurotrauma·Asla Pitkänen, Tracy K McIntosh
Mar 21, 2018·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Richard WennbergCharles H Tator
May 7, 2021·Epilepsy & Behavior : E&B·Ayataka FujimotoTohru Oanishi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.