Exacerbation of Thromboinflammation by Hyperglycemia Precipitates Cerebral Infarct Growth and Hemorrhagic Transformation

Stroke; a Journal of Cerebral Circulation
Jean-Philippe DesillesBenoit Ho-Tin-Noe

Abstract

Admission hyperglycemia is associated with a poor outcome in acute ischemic stroke. How hyperglycemia impacts the pathophysiology of acute ischemic stroke remains largely unknown. We investigated how preexisting hyperglycemia increases ischemia/reperfusion cerebral injury. Normoglycemic and streptozotocin-treated hyperglycemic rats were subjected to transient middle cerebral artery occlusion. Infarct growth and brain perfusion were assessed by magnetic resonance imaging. Markers of platelet, coagulation, and neutrophil activation were measured in brain homogenates and plasma. Downstream microvascular thromboinflammation (DMT) was investigated by intravital microscopy. Hyperglycemic rats had an increased infarct volume with an increased blood-brain barrier disruption and hemorrhagic transformation rate compared with normoglycemic rats. Magnetic resonance imaging scans revealed that hyperglycemia enhanced and accelerated lesion growth and was associated with hemorrhagic transformation originating from territories that were still not completely reperfused at 1 hour after middle cerebral artery recanalization. Intravital microscopy and analysis of brain homogenates showed that DMT began immediately after middle cerebral artery occl...Continue Reading

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Citations

Mar 3, 2018·Journal of the American Heart Association·Jean-Philippe DesillesBenoît Ho-Tin-Noé
Jul 1, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G ZhangL Pang
May 5, 2018·Stroke; a Journal of Cerebral Circulation·Kyeong-A KimOk-Nam Bae
Apr 20, 2018·Stroke; a Journal of Cerebral Circulation·Julie BernhardtMichael Tymianski
May 31, 2019·Journal of Neurointerventional Surgery·William K DiproseP Alan Barber
Jul 28, 2018·Translational Stroke Research·Manuel Navarro-OviedoJosune Orbe
May 16, 2018·Stroke; a Journal of Cerebral Circulation·Angelika HoffmannMirko Pham
Jul 19, 2019·Stem Cell Research & Therapy·Mari Carmen Gómez-de FrutosUNKNOWN RESSTORE consortium
Oct 21, 2020·Journal of Neurointerventional Surgery·Philipp TausskyAdam de Havenon
Oct 31, 2020·Cellular and Molecular Neurobiology·Chengli LiuWei Wang
Oct 30, 2020·Journal of Thrombosis and Haemostasis : JTH·Frederik DenormeRobert A Campbell
Sep 15, 2020·Stroke; a Journal of Cerebral Circulation·Jean-Baptiste GirotUNKNOWN ETIS Investigators*
Dec 29, 2020·Frontiers in Neurology·Benjamin MaïerMikael Mazighi
Mar 12, 2021·Clinical Neuroradiology·Adrien GuenegoUNKNOWN ETIS investigators
Apr 3, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Eva A RochaAneesh B Singhal
Apr 1, 2021·Cellular and Molecular Neurobiology·Devendra SinghK H Reeta
May 1, 2021·International Journal of Molecular Sciences·Coline GrisottoDavid Couret
Jun 1, 2021·Frontiers in Neurology·Elena SpronkGlen C Jickling
Jul 17, 2021·Neural Regeneration Research·Federica FerrariRoberto Federico Villa
Sep 23, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jose Danilo Bengzon DiestroJulian Spears

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