Exacerbation of tumor necrosis factor-induced vascular leak syndrome by aging

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Kyung-Yeon ParkTae-Hwe Heo

Abstract

Aging is associated with upregulation of tumor necrosis factor (TNF) and increased vascular inflammation. TNF is a major proinflammatory cytokine that contributes to both vascular inflammation and vascular leak syndrome (VLS). The purpose of this study was to investigate whether the aging affects TNF-induced VLS. Vascular leak, histology, and cytokine assays were performed in young and aged groups of wild-type and TNF overexpressing transgenic (Tg) mice. An aged group of TNF Tg mice showed substantially amplified VLS compared with young Tg mice. Age-related amplification of TNF-induced VLS appears to be related to local vascular fibrosis and the systemic upregulation of TNF and MCP-1 levels in older TNF Tg mice. Our finding suggests that chronic high-grade TNF exposure could mediate the severe vascular pathogenicity of VLS.

References

Dec 24, 1997·Immunopharmacology·R Baluna, E S Vitetta
Dec 16, 2004·Herz·Zoltan UngvariGabor Kaley
Aug 18, 2006·International Immunology·Louise MelencioMitzi Nagarkatti
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carsten KriegOnur Boyman
Jun 26, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan UngvariAnna Csiszar
Jul 20, 2010·Free Radical Biology & Medicine·David de Gonzalo-CalvoAna Coto-Montes
Nov 20, 2012·Current Opinion in Lipidology·Fleur M van der ValkErik S G Stroes
Jan 22, 2013·Nature Reviews. Drug Discovery·Michael CroftCarl F Ware
Jul 16, 2013·Free Radical Biology & Medicine·Mariam El AssarLeocadio Rodríguez-Mañas
Mar 18, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kyung-Yeon ParkTae-Hwe Heo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.