Exact matching of trabectome-mediated ab interno trabeculectomy to conventional trabeculectomy with mitomycin C followed for 2 years

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Alicja StrzalkowskaNils A Loewen

Abstract

We used exact matching for a highly balanced comparison of ab interno trabeculectomy (AIT) with the trabectome to trabeculectomy with mitomycin C (TRAB). A total of 5485 patients who underwent AIT were exact-matched to 196 TRAB patients by baseline intraocular pressure (IOP), number of glaucoma medications, and glaucoma type. Nearest-neighbor-matching was applied to age. Success was defined as a final IOP of less than 21 mmHg, IOP reduction of at least 20% reduction from baseline, and no secondary surgical interventions. Outcomes were measured at 1, 3, 6, 12, 18, and 24 months. A total of 165 AIT could be matched to 165 TRAB. The mean baseline IOP was 22.3 ± 5.6 mmHg, and the baseline number of glaucoma medications was 2.7 ± 1.1 in both groups. At 24 months, IOP was reduced to 15.8 ± 5.2 mmHg in AIT and 12.4 ± 4.7 mmHg in TRAB. IOP was lower than baseline at all visits (p < 0.01) and lower in TRAB than AIT (p < 0.01). Glaucoma medications were reduced to 2.1 ± 1.3 in AIT and 0.2 ± 0.8 in TRAB. Compared to baseline, patients used fewer drops postoperatively (p < 0.01) and more infrequently in TRAB than in AIT (p > 0.01). Secondary surgical interventions had the highest impact on success and became necessary in 15 AIT and 59 TRAB...Continue Reading

References

Jan 1, 1990·Journal of Ocular Pharmacology·C W ChenC C Lee
Jan 27, 1999·Progress in Retinal and Eye Research·E Lütjen-Drecoll
Sep 12, 2000·Archives of Ophthalmology·D H Johnson, Y Matsumoto
Aug 9, 2001·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·G PichtFranz Grehn
Dec 26, 2001·Archives of Ophthalmology·AGIS (Advanced Glaucoma Intervention Study) Investigators
Jul 3, 2002·Ophthalmology·Rajiv BindlishRichard Lehrer
Feb 5, 2003·American Journal of Ophthalmology·Camille HyltonHenry D Jampel
Dec 3, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Dirk MarquardtFranz Grehn
Aug 2, 2005·Ophthalmology Clinics of North America·Mark A Latina, John Mark S de Leon
Aug 10, 2005·American Journal of Ophthalmology·Steven J GeddeTube versus Trabeculectomy Study Group
Oct 24, 2006·American Journal of Ophthalmology·Steven J GeddeJoyce C Schiffman
Sep 8, 2007·Experimental Eye Research·Douglas H Johnson
Jun 24, 2008·Journal of Cataract and Refractive Surgery·Brian A FrancisTrabectome Study Group
Aug 30, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Katsuhiko Maruyama, Shiroaki Shirato
Sep 28, 2010·Statistical Science : a Review Journal of the Institute of Mathematical Statistics·Elizabeth A Stuart
Jan 17, 2012·American Journal of Ophthalmology·Steven J GeddeTube versus Trabeculectomy Study Group
May 23, 2012·Ophthalmology·Steven L MansbergerOcular Hypertension Treatment Study Group
Jan 29, 2013·The British Journal of Ophthalmology·Simon K LawJoseph Caprioli
May 1, 2013·American Journal of Ophthalmology·Hyun Seung YangSangkyung Choi
Oct 23, 2013·Journal of Glaucoma·Osamah J SaeediHarry A Quigley
Oct 26, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jens F JordanMatthias Neuburger
Jan 15, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Matthias K J KlamannNecip Torun
Aug 30, 2014·The British Journal of Ophthalmology·Igor I BusselTrabectome Study Group
Oct 23, 2014·The British Journal of Ophthalmology·Igor I BusselTrabectome Study Group
Jan 7, 2016·The British Journal of Ophthalmology·Kevin KaplowitzNils A Loewen
May 23, 2017·F1000Research·Katherine FallanoNils A Loewen
Sep 26, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tigran KostanyanNils A Loewen
Apr 11, 2018·American Journal of Physiology. Cell Physiology·Fiona McDonnellW Daniel Stamer
May 4, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yalong DangNils A Loewen
Sep 14, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xue YinPeirong Lu
Dec 7, 2018·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Jessica L M TingKarim F Damji
Apr 30, 2019·Journal of Cataract and Refractive Surgery·Hamed EsfandiariNils A Loewen
Nov 16, 2019·Ophthalmology·Steven J GeddePrimary Tube Versus Trabeculectomy Study Group
May 7, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Si ChenNils A Loewen
Sep 23, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yousef Al YousefNils A Loewen

Related Concepts

Mitomycin
Glaucoma
Trabeculectomy
Proximal
Intraocular Pressure Test
Operative Surgical Procedures
Explanation of Plan: Medication
TRABD2B gene

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.