May 2, 2020

Modeling and Analyzing Neural Signals with Phase Variability using the Fisher-Rao Registration

BioRxiv : the Preprint Server for Biology
W. ZhaoWei Wu


The Dynamic Time Warping (DTW) has recently been introduced to analyze neural signals such as EEG and fMRI where phase variability plays an important role in the data. In this study, we propose to adopt a more powerful method, referred to as the Fisher-Rao Registration (FRR), to study the phase variability. We systematically compare the FRR with the DTW in three aspects: 1) basic framework, 2) mathematical properties, and 3) computational efficiency. We show that the FRR has superior performance in all these aspects and the advantages are well illustrated with simulation examples. We then apply the FRR method to two real experimental recordings -- one fMRI and one EEG data set. It is found the FRR method properly removes the phase variability in each set. Finally, we use the FRR framework to examine brain networks in these two data sets and the result demonstrates the effectiveness of the new method.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Laboratory Procedures
Protein Methylation
Neurodevelopmental Disorders
Autistic Disorder
Study of Epigenetics
Structure of Cortex of Kidney

Related Feeds

Autism: Treatment Targets

The absence of effective treatments for autism are due to the high clinical and genetic heterogeneity between affected individuals, restricted knowledge of the underlying pathophysiological mechanisms, and the lack of reliable diagnostic biomarkers. Identification of more homogenous biological subgroups is therefore essential for the development of novel treatments based on the molecular mechanisms underpinning autism and autism spectrum disorders. Find the latest research on autism treatment targets here.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.


Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research.