Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and Caucasians

Diabetic Medicine : a Journal of the British Diabetic Association
N StefanR E Pratley

Abstract

African-Americans have a higher prevalence of Type 2 diabetes than Caucasians, but a lower prevalence than Pima Indians. Studies suggest that both African-Americans and Pima Indians are more insulin resistant and have higher acute insulin secretory responses to glucose than Caucasians; however, a direct comparison between these three populations is lacking. We measured insulin secretory responses to intravenous glucose (acute insulin response, AIR, 25 g ivGTT); insulin action at physiological (M-low) and supra-physiological (M-high) levels of hyperinsulinaemia (2-step hyperinsulinaemic clamp); basal and insulin-suppressed endogenous glucose production in 30 African-Americans, 30 Pima Indians and 30 Caucasians with normal glucose tolerance who were carefully matched for age, sex, and body fat (hydrodensitometry or DEXA). A subgroup of 24 subjects from each group additionally underwent a standardized mixed meal test. M-low was lower in Pima Indians (0.50 +/- 0.03) compared to Caucasians (0.59 +/- 0.02, P = 0.02) and African-Americans [0.58 +/- 0.03 mg/kgEMBS/min, log10 (means +/- SE), P = 0.03] but was not different between African-Americans and Caucasians. Basal endogenous glucose production was lower in Pima Indians (2.43 +/- 0...Continue Reading

References

Feb 1, 1990·Diabetes/metabolism Reviews·W C KnowlerP H Bennett
Aug 1, 1990·Metabolism: Clinical and Experimental·S M HaffnerR N Bergman
Dec 8, 1988·The New England Journal of Medicine·M F SaadP H Bennett
Apr 1, 1985·The Journal of Clinical Investigation·S LilliojaB V Howard
Sep 1, 1996·Metabolism: Clinical and Experimental·J C LovejoyR Tulley
Dec 1, 1996·The American Journal of Clinical Nutrition·J A YanovskiM Flood
May 16, 1998·The American Journal of Clinical Nutrition·B A GowerM I Goran

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Citations

Jan 22, 2014·Current Diabetes Reports·Tanya L AldereteMichael I Goran
Mar 4, 2008·American Journal of Preventive Medicine·Janice L ThompsonCarla J Herman
Mar 31, 2005·Metabolism: Clinical and Experimental·Alexandra J BuckleyCampbell H Thompson
Feb 21, 2009·Diabetes Care·Marie S ThearleJonathan Krakoff
Jun 14, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S HeinitzR Jumpertz von Schwartzenberg
Sep 17, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Elvira Isganaitis, Robert H Lustig
Aug 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Sascha HeinitzPaolo Piaggi
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Feb 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Stella P KimRichard N Bergman
Jun 4, 2020·Diabetes, Obesity & Metabolism·Meera LadwaLouise M Goff
Jan 5, 2018·The Journal of Clinical Endocrinology and Metabolism·Sascha HeinitzJonathan Krakoff
Jun 7, 2011·Expert Review of Endocrinology & Metabolism·Mark D Deboer
Oct 24, 2006·The Journal of Nutrition·Xochitl PonceHélène Delisle
Jul 17, 2019·The Proceedings of the Nutrition Society·Louise M GoffOluwatoyosi Bello
May 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Latif ArmiyawRanganath Muniyappa
Sep 28, 2017·Diabetes/metabolism Research and Reviews·Sascha HeinitzJonathan Krakoff
Nov 30, 2019·Journal of Diabetes Research·M LadwaL M Goff
May 11, 2021·Frontiers in Physiology·Joon HaMichael J Quon

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