Examination of a second region of the HIV type 1 genome reveals additional cases of superinfection.

AIDS Research and Human Retroviruses
Anne PiantadosiJulie Overbaugh

Abstract

HIV-1 superinfection may occur at a rate similar to that of initial infection, raising concerns for HIV-1 vaccine strategies predicated on eliciting immune responses similar to those in natural infection. Because of the high rate of recombination during HIV-1 replication, studies examining only one region of the HIV-1 genome are likely to miss cases of HIV-1 superinfection. We examined HIV-1 gag sequences from 14 high-risk Kenyan women in whom superinfection was not detected in a previous study of env sequences. We detected two additional cases of HIV-1 superinfection: one intersubtype superinfection that occurred between 1046 and 1487 days postinfection (DPI) and one intrasubtype superinfection that occurred between 341 and 440 DPI. Our results suggest that studies that examine only small genome regions may lead to underestimates of the risk of superinfection, highlighting the need for more extensive studies examining multiple regions of the HIV-1 genome.

References

Apr 1, 1999·The Journal of Infectious Diseases·J OverbaughJ Bwayo
Jan 11, 2000·Journal of Virology·A E JetztJ P Dougherty
Sep 9, 2004·JAMA : the Journal of the American Medical Association·Davey M SmithSusan J Little
Apr 6, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ludo LavreysJulie Overbaugh
Nov 21, 2007·PLoS Pathogens·Anne PiantadosiJulie Overbaugh

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Citations

Jun 4, 2013·The Lancet Infectious Diseases·Andrew D ReddAaron A R Tobian
Oct 20, 2010·AIDS Research and Human Retroviruses·Mary PacoldSergei Kosakovsky Pond
Nov 20, 2010·AIDS Research and Human Retroviruses·Antoinette C van der KuylMarion Cornelissen
Dec 14, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marion CornelissenAntoinette C van der Kuyl
Jun 8, 2012·The Journal of Infectious Diseases·Andrew D ReddThomas C Quinn
Jun 24, 2011·Journal of Clinical Microbiology·Andrew D ReddUNKNOWN Rakai Health Sciences Program
Dec 14, 2011·Journal of Clinical Microbiology·Gonzalo YebraUNKNOWN Cohort of the Spanish AIDS Research Network (CoRIS)
Sep 26, 2014·Viruses·Jonathan M O Rawson, Louis M Mansky
Feb 25, 2010·Journal of Virological Methods·Andrea RachingerAngélique B van 't Wout
Jan 19, 2016·Mathematical Biosciences and Engineering : MBE·Xiaodan SunZhihang Peng
Feb 6, 2015·PLoS Computational Biology·Bence FerdinandyViktor Müller
Dec 14, 2011·Current Opinion in Infectious Diseases·Laura Waters, Erasmus Smit
May 11, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hong LuanHong Shang
Apr 7, 2018·PloS One·Laura HebberechtChris Verhofstede
Dec 29, 2013·Journal of Clinical Microbiology·Andrew D ReddSalim S Abdool Karim
May 30, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·María PernasCecilio López Galíndez
Feb 6, 2020·PLoS Pathogens·Mark D PankauDara A Lehman
Aug 8, 2018·Frontiers in Microbiology·Ágnes MóréhViktor Müller

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