Abstract
1. Coumarins, flavonoids and polysaccharopeptide were tested for antibacterial activity. 2. The bacteria used for this study included clinical isolates of Staphylococcus aureus, Shigella flexneri, Salmonella typhi, Escherichia coli and Pseudomonas aeruginosa. 3. Most of the coumarins tested failed to inhibit the bacteria at 25 mg/l. Edultin at 128 mg/l inhibited 4 of the 8 P. aeruginosa strains and 1 of the S. aureus strains tested. O-acetylcolumbianetin and imperatorin did not inhibit any isolate, even at 128 mg/l. 4. When tested at the dose of 128 mg/l, the flavonoids (rutin, naringin and baicalin) inhibited 25% or less of P. aeruginosa and only baicalin was active against S. aureus. 5. Arbutin and 4-(beta-D-glucopyranosyloxyl)-benzaldehyde inhibited 3 of the 8 P. aeruginosa strains when tested at 128 mg/l. 6. Polysaccharopeptide from the fungus Coriolus versicolor failed to inhibit any P. aeruginosa or S. aureus strain at 128 mg/l.
References
Mar 27, 1992·Biochemical Pharmacology·E Middleton, C Kandaswami
May 15, 1989·Biochemical Pharmacology·P C FerriolaE Middleton
Oct 3, 1983·European Journal of Biochemistry·Y GrazianiR L Erikson
Oct 31, 1983·Biochemical and Biophysical Research Communications·T YoshimotoS Watanabe-Kohno
Sep 1, 1981·Journal of Natural Products·K H LeeJ S Lai
Sep 1, 1993·Immunopharmacology·W K LiuK W Tsui
Citations
Dec 25, 2009·Inflammation·Yong-Jun TangShao-Jie Yue
Jan 5, 2002·Biochemical Pharmacology·Y F UengC F Chen
Feb 19, 2000·Life Sciences·T B NgZ T Wang
Nov 28, 2002·Pharmacology & Therapeutics·Bent H Havsteen
Nov 14, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·U J JungM S Choi
Aug 7, 2002·Journal of Clinical Pharmacology·Gernot SchindlerMarkus Veit
Jun 18, 2015·Nutrients·Joon Hyeong ChoSe Chan Kang
Sep 4, 2010·European Journal of Pharmacology·Yan ZhangLang Chong He
Dec 3, 2005·International Journal of Antimicrobial Agents·T P Tim Cushnie, Andrew J Lamb
Apr 30, 2016·Journal of Pathogens·Tommaso CaiRiccardo Bartoletti
Jun 18, 2011·Fitoterapia·Yan ZhangLangChong He
Aug 24, 2001·The Journal of Pharmacy and Pharmacology·M J AbadA M Villar
Jan 14, 2004·Microbiological Research·T P Tim CushnieAndrew J Lamb
Apr 26, 2006·Pharmacology·Guo-fang WangFa-ming Chen
Feb 17, 2001·Phytotherapy Research : PTR·H X Xu, S F Lee
Feb 9, 2011·Sexually Transmitted Diseases·Paulina CybulskaJo-Anne R Dillon
Nov 13, 2019·Phytopathology·Christopher Michael FerenceElizabeth Baldwin
Nov 15, 2001·Journal of Cardiovascular Pharmacology·S C ChoeY B Park
Sep 25, 2020·Journal of Animal Physiology and Animal Nutrition·Abdel-Moneim E Abdel-MoneimMohamed E Abd El-Hack
Dec 22, 2020·Therapeutic Advances in Musculoskeletal Disease·Kristin E YuFrancis Y Lee
Mar 13, 2021·Frontiers in Pharmacology·Sajad FakhriJavier Echeverría
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José M Cela-LópezVicente Martínez