PMID: 8981074Oct 1, 1996Paper

Examination of coumarins, flavonoids and polysaccharopeptide for antibacterial activity

General Pharmacology
T B NgG J Xu

Abstract

1. Coumarins, flavonoids and polysaccharopeptide were tested for antibacterial activity. 2. The bacteria used for this study included clinical isolates of Staphylococcus aureus, Shigella flexneri, Salmonella typhi, Escherichia coli and Pseudomonas aeruginosa. 3. Most of the coumarins tested failed to inhibit the bacteria at 25 mg/l. Edultin at 128 mg/l inhibited 4 of the 8 P. aeruginosa strains and 1 of the S. aureus strains tested. O-acetylcolumbianetin and imperatorin did not inhibit any isolate, even at 128 mg/l. 4. When tested at the dose of 128 mg/l, the flavonoids (rutin, naringin and baicalin) inhibited 25% or less of P. aeruginosa and only baicalin was active against S. aureus. 5. Arbutin and 4-(beta-D-glucopyranosyloxyl)-benzaldehyde inhibited 3 of the 8 P. aeruginosa strains when tested at 128 mg/l. 6. Polysaccharopeptide from the fungus Coriolus versicolor failed to inhibit any P. aeruginosa or S. aureus strain at 128 mg/l.

References

Mar 27, 1992·Biochemical Pharmacology·E Middleton, C Kandaswami
Oct 31, 1983·Biochemical and Biophysical Research Communications·T YoshimotoS Watanabe-Kohno

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Citations

Feb 19, 2000·Life Sciences·T B NgZ T Wang
Nov 28, 2002·Pharmacology & Therapeutics·Bent H Havsteen
Nov 14, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·U J JungM S Choi
Dec 3, 2005·International Journal of Antimicrobial Agents·T P Tim Cushnie, Andrew J Lamb
Jun 18, 2011·Fitoterapia·Yan ZhangLangChong He
Aug 24, 2001·The Journal of Pharmacy and Pharmacology·M J AbadA M Villar
Feb 17, 2001·Phytotherapy Research : PTR·H X Xu, S F Lee
Nov 13, 2019·Phytopathology·Christopher Michael FerenceElizabeth Baldwin
Sep 25, 2020·Journal of Animal Physiology and Animal Nutrition·Abdel-Moneim E Abdel-MoneimMohamed E Abd El-Hack
Dec 22, 2020·Therapeutic Advances in Musculoskeletal Disease·Kristin E YuFrancis Y Lee
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José M Cela-LópezVicente Martínez

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