Examination of periodontal pathogens in stenotic valve specimens and in whole blood samples in patients affected by aortic valve stenosis and chronic periodontitis

International Journal of Immunopathology and Pharmacology
L RaffaelliA D'Addona

Abstract

Periodontitis may be a risk factor for atherosclerosis and coronary heart disease. The influence of periodontal pathogens in cardiovascular diseases needs further investigation. Therefore, the aims of this clinical study are: to test the presence of periodontal bacteria DNA in aortic valves and to assess the concomitant presence of the same periodontal bacteria DNA in whole blood samples in patients affected by aortic valve stenosis and chronic periodontitis. Nineteen consecutive patients (12 males and 7 females, age: 49-85 years) were enrolled in this study after having been subjected to a complete periodontal evaluation to confirm the diagnosis of chronic periodontitis. All patients were scheduled for aortic valve replacement surgery. After clinical and microbial periodontal examination, the aortic valve tissue specimens were obtained by excision during valve replacement surgery and the patients were subjected to the whole blood sampling before the surgery. The polymerase chain reaction technology was used to detect the putative periodontal pathogens Tannerella forshytia, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Fusobacterium nucleatum, Campylobacter rectus, Eikenella corrodens a...Continue Reading

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Citations

Dec 19, 2013·Lasers in Medical Science·Nikolaos S SoukosJ Max Goodson
Mar 12, 2015·Lasers in Medical Science·Carla R FontanaNikolaos S Soukos
Apr 8, 2014·Virulence·Małgorzata Radwan-OczkoWojciech Kustrzycki
Apr 25, 2014·Virulence·Georgios BelibasakisNagihan Bostanci
Jun 2, 2021·Journal of Clinical Periodontology·Sung-Kien SiaJames Cheng-Chung Wei
Aug 14, 2021·Journal of Periodontal & Implant Science·Akihisa KataokaKen Kozuma

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