Examination of Physiologically-Based Pharmacokinetic Models of Rosuvastatin.

CPT: Pharmacometrics & Systems Pharmacology
Christine M BowmanYuan Chen

Abstract

Physiologically-based pharmacokinetic (PBPK) modeling is increasingly used to predict drug disposition and drug-drug interactions (DDIs). However, accurately predicting the pharmacokinetics of transporter substrates and transporter-mediated DDIs (tDDIs) is still challenging. Rosuvastatin is a commonly used substrate probe in DDI risk assessment for new molecular entities (NMEs) that are potential organic anion transporting polypeptide 1B or breast cancer resistance protein transporter inhibitors, and as such, several rosuvastatin PBPK models have been developed to try to predict the clinical DDI and support NME drug labeling. In this review, we examine five representative PBPK rosuvastatin models, discuss common challenges that the models have come across, and note remaining gaps. These shared learnings will help with the continuing efforts of rosuvastatin model validation, provide more information to understand transporter-mediated drug disposition, and increase confidence in tDDI prediction.

References

Sep 26, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K NezasaM Koike
Oct 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ken-ichi NezasaMasahiro Koike
Oct 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomayant PrueksaritanontJiunn H Lin
Dec 14, 2002·Cardiovascular Drug Reviews·Anders G OlssonAli Raza
Jan 22, 2003·British Journal of Clinical Pharmacology·Kelvin J CooperDennis W Schneck
Apr 19, 2003·European Journal of Clinical Pharmacology·K J CooperD W Schneck
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Daisuke KobayashiIkumi Tamai
Dec 12, 2003·Clinical Therapeutics·Paul D MartinTracy Short
Apr 30, 2004·Clinical Pharmacology and Therapeutics·Dennis W SchneckAli Raza
Aug 4, 2004·Clinical Pharmacology and Therapeutics·Steven G SimonsonDennis W Schneck
Apr 2, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H FujinoT Sakaeda
Oct 26, 2005·Experimental Biology and Medicine·Nazzareno Ballatori
Jan 18, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Liyue HuangScott Grimm
Apr 6, 2006·Pflügers Archiv : European journal of physiology·Piet BorstKoen van de Wetering
Jun 30, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ebba BergmanHans Lennernäs
Mar 21, 2007·Pharmaceutical Research·Trudy Rodgers, Malcolm Rowland
Jun 2, 2007·Journal of Pharmaceutical Sciences·Donna A Volpe
Jun 23, 2007·The Journal of Pharmacology and Experimental Therapeutics·A S WindassC D A Brown
Jul 10, 2008·Molecular Pharmacology·Anja VerhulstColin D A Brown
Jul 12, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Satoshi KitamuraYuichi Sugiyama
Dec 17, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Koji AbeKim L R Brouwer
Apr 22, 2009·The AAPS Journal·Masoud JameiGeoffrey Tucker
Apr 29, 2009·The AAPS Journal·Anita Grover, Leslie Z Benet
May 29, 2009·Clinical Pharmacology and Therapeutics·J E KeskitaloM Niemi
Sep 30, 2009·British Journal of Pharmacology·A Kalliokoski, M Niemi
Mar 31, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jibin LiIsmael J Hidalgo
Jun 16, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Naoki KotaniYuichi Sugiyama
Jul 19, 2011·Journal of Pharmaceutical Sciences·Li DiMatthew D Troutman
Feb 22, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hannah M JonesKatherine S Fenner
Sep 17, 2013·British Journal of Clinical Pharmacology·Nikolaos TsamandourasLeon Aarons
Mar 13, 2014·British Journal of Clinical Pharmacology·Thomayant PrueksaritanontS Aubrey Stoch
May 7, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anna VildhedePer Artursson
Sep 28, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sieto BosgraHeleen M Wortelboer
Jan 1, 2013·In Silico Pharmacology·Masoud JameiAmin Rostami-Hodjegan
Sep 29, 2015·Molecular Pharmaceutics·Tom J J SchirrisFrans G M Russel
Aug 6, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Howard J BurtSibylle Neuhoff

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

Simcyp
Simcyp Simulator
IV

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.