PMID: 6978676Jan 1, 1981Paper

Examination of possible mechanisms by which stimulation of the spinal cord in man relieves pain

Applied Neurophysiology
J N Campbell

Abstract

Stimulation of the spinal cord may be very helpful in controlling chronic pain. Traditionally it has been thought that pain control derives from antidromic activation of large-diameter primary afferents in the posterior columns, which inhibits activation of second-order neurons. Evidence against this hypothesis is presented. In addition, it is pointed out that stimulation of the anterolateral quadrant contralateral to the side of pain may require less current for pain control than stimulation with electrodes over the posterior cord. It is suggested that 'frequency-related conduction block' in the spinothalamic tract or in Lissauer's tract may play a role in pain relief. Because of uncertainty about the mechanism it is suggested that the term 'dorsal column stimulation' be replaced by 'spinal axis stimulation'.

Citations

Feb 1, 1986·Journal of Neurology·H P VogelC Wagner
May 23, 2012·Current Pain and Headache Reports·Artemus FlaggKayode Williams
Jan 1, 1983·Progress in Biophysics and Molecular Biology·E Syková
Jan 1, 2005·Neuromodulation : Journal of the International Neuromodulation Society·Yasin N KhanElizabeth A Khan
Mar 8, 2007·Neurosurgical Focus·Oren Sagher, Dah-Luen Huang
Apr 1, 2004·Neuromodulation : Journal of the International Neuromodulation Society·Elliot Krames, Demian G Mousad
Mar 13, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Zhiyang SongBengt Linderoth
Oct 14, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Fei YangYun Guan
Mar 13, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Ganesan BaranidharanKarthikeyan Dhandapani
Sep 22, 2000·Current Review of Pain·D Lynch
Apr 24, 2012·Pain Practice : the Official Journal of World Institute of Pain·Corey HunterTimothy Deer

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