Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells.

Journal of Enzyme Inhibition and Medicinal Chemistry
Alisha PooleVincent C Chen

Abstract

Glioblastoma multiforme (GBM) is the deadliest and the most common primary malignant brain tumour. The median survival for patients with GBM is around one year due to the nature of glioma cells to diffusely invade that make the complete surgical resection of tumours difficult. Based upon the connexin43 (Cx43) model of glioma migration we have developed a computational framework to evaluate MMP inhibition in materials relevant to GBM. Using the ilomastat Leu-Trp backbone, we have synthesised novel sulphonamides and monitored the performance of these compounds in conditioned media expressing MMP3. From the results discussed herein we demonstrate the performance of sulfonamide based MMPIs included AP-3, AP-6, and AP-7.

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Citations

Aug 21, 2021·Frontiers in Veterinary Science·Catrin S RutlandNigel P Mongan

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Methods Mentioned

BETA
surgical resection
column chromatography
NMR
flash
flow cytometry

Software Mentioned

MOE ( Molecular Operating Environment )
MOE
MD
ImageJ

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