Examination of surface properties and in vitro biological performance of amorphous diamond-like carbon-coated polyurethane

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
David S JonesSean P Gorman

Abstract

Despite the emerging use of diamond-like carbon (DLC) as a coating for medical devices, few studies have examined the resistance of DLC coatings onto medical polymers to both microbial adherence and encrustation. In this study, amorphous DLC of a range of refractive indexes (1.7-1.9) and thicknesses (100-600 nm) was deposited onto polyurethane, a model polymer, and the resistance to microbial adherence (Escherichia coli; clinical isolate) and encrustation examined using in vitro models. In comparison to the native polymer, the advancing and receding contact angles of DLC-coated polyurethane were lower, indicating greater hydrophilic properties. No relationship was observed between refractive index, thickness, and advancing contact angle, as determined using multiple correlation analysis. The resistances of the various DLC-coated polyurethane films to encrustation and microbial adherence were significantly greater than that to polyurethane; however, there were individual differences between the resistances of the various DLC coatings. In general, increasing the refractive index of the coatings (100 nm thickness) decreased the resistance of the films to both hydroxyapatite and struvite encrustation and to microbial adherence. Fil...Continue Reading

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Citations

Jun 3, 2010·Urological Research·Nandakumar VenkatesanMukesh Doble
Jan 19, 2011·Journal of Materials Science. Materials in Medicine·Antti SoininenYannis Missirlis
Jan 16, 2010·Journal of Endourology·Nandakumar VenkatesanMukesh Doble
Jul 8, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sheryl R KaneLisa A Pruitt
May 25, 2012·Journal of Biomedical Materials Research. Part a·G Del PradoJ Esteban
Apr 9, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Antti SoininenPrashant K Sharma
Mar 18, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shunmugaperumal TamilvananAnnick Ludwig
Nov 3, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Tommaso MazzocchiLeonardo Ricotti

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