May 1, 1978

Examination of the action of effectors after storing glutamine synthetase from the fodder yeast Candida tropicalis at room temperature

Prikladnaia biokhimiia i mikrobiologiia
T L Auérman, T I Uralets


The pattern of action of effectors (AMP, IMP, CMP, anthranilic acid, tryptophane, alanine, glutamine, glycine, histidine) and glutamine synthetase (GS) extracted from the fodder yeast Candida tropicalis and stored at room temperature for 1.5-2 hrs was examined. As regards the action of effectors on GS after its exposure at room temperature, they can be subdivided into four groups: 1) the effector loses completely its inhibitory effect (glutamine, CMP, anthranilic acid in the synthetase reaction); 2) the inhibitory effect on the enzyme increases (AMP, IMP, anthranilic acid in the transferase reaction); 3) at low concentrations of the effector the peak of activation appears (tryptophane, GMP, alanine, glycine); 4) at low concentrations of the enzyme two peaks of activation appear (histidine). Similar results were obtained with the purified preparation of GS.

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Mentioned in this Paper

Anthranilic acid
Glutamine Deficiency, Congenital
Glutamate-Ammonia Ligase
GLUL gene
Glycine (Plant)
Candida tropicalis allergenic extract
Drug Stability

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